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FLASH GENE
Symbol IVL contributors: mct - updated : 25-05-2011
HGNC name involucrin
HGNC id 6187
Location 1q21.3      Physical location : 152.881.038 - 152.884.361
Synonym symbol(s) INVC
DNA
TYPE functioning gene
STRUCTURE 3.32 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • open reading frame in a single exon
  • regulatory transcription factor binding sites (AP1), for regulation of expression during early versus late epidermal differentiation
  • binding sites for AP-1 (activator protein 1) and Sp1 transcription factors important for promoter activity and tissue-specific expression
  • MAPPING cloned Y linked N status confirmed
    Map see EDC
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2165 - 585 - 1996 8618063
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelialbarrier/lining   
    skin tegumentdermis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein glutamine/glutamate rich, with 39 octapeptide repeats in the central region
  • HOMOLOGY
    interspecies ortholog to murine Ivl
    homolog to C.elegans C25A11.4B
    Homologene
    FAMILY
  • SPRR family
  • involucrin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosol protein ultimately cross-linked to membrane by transglutaminase
    basic FUNCTION
  • functioning as a keratinocyte protein
  • marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia
  • with EVPL, and PPL, form the protein scaffold on which the cornified envelope assembles
  • Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • precursor of cornified cell enveloppe (major constituent of keratinocyte cross-linked enveloppe)
  • PRMT5/WDR77-dependent methylation is an epigenetic mechanism that assists in silencing of IVL expression, and PRKCD signaling activates gene expression by directly activating transcription and by suppressing PRMT5/WDR77-dependent arginine dimethylation of promoter-associated histones
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by Th2 cytokines that inhibit expression of LOR and IVL through a STAT-6 dependent mechanism
    repressed by overexpression of POU2F2 (repression of promoter activity in epithelial cells and in the presence of the silencer element)
    Other regulated by PCAF and CREBBP in stratified squamous epithelial cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS