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FLASH GENE
Symbol ITPKB contributors: mct/npt - updated : 14-11-2018
HGNC name inositol 1,4,5-trisphosphate 3-kinase B
HGNC id 6179
Location 1q42.12      Physical location : 226.819.391 - 226.926.876
Synonym name
  • IP3 3-kinase
  • proliferation-inducing protein 37
  • 1D-myo-inositol-trisphosphate 3-kinase B
  • Synonym symbol(s) IP3K, IP3KB, PIG37
    EC.number 2.7.1.127
    DNA
    TYPE functioning gene
    STRUCTURE 105.97 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D1S439 - ITPKB - D1S251 - D1S459 - D1S437 - D1S235 - D1S204 - D1S609 - D1S2682 - qter
    Authors White (99)
    Physical map
    LOC388747 1 similar to RIKEN cDNA A230079K17 LOC127602 1q42.13 similar to KIAA1697 protein LBR 1q42.1 lamin B receptor ENAH 1q41 enabled homolog (Drosophila) SRP9 1q42.13 signal recognition particle 9kDa LEFTY3 1q42.1 LEFTY family pseudogene EPHX1 1q42.1 epoxide hydrolase 1, microsomal (xenobiotic) KIAA0792 1q42.13 epoxide hydrolase 1, microsomal (xenobiotic) LEFTB 1q42.1 left-right determination, factor B P5CR2 1q42.13 pyrroline 5-carboxylate reductase isoform EBAF 1q42.1 endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily) FLJ35382 1q42.13 hypothetical protein FLJ35382 H3F3A 1q41 H3 histone, family 3A ACBD3 1q42.13 acyl-Coenzyme A binding domain containing 3 MIXL1 1q41 Mix1 homeobox-like 1 (Xenopus laevis) TGS 1q42.13 TUDOR gene similar ADPRT 1q42 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) LOC391168 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC391169 1 similar to hypothetical protein D11Ertd497e LOC388748 1 LOC388748 LOC388749 1 LOC388749 ITPKB 1q41-q42 inositol 1,4,5-trisphosphate 3-kinase B LOC391170 1 similar to hypothetical protein PSEN2 1q42.1 presenilin 2 (Alzheimer disease 4) CABC1 1q42.11 chaperone, ABC1 activity of bc1 complex like (S. pombe) CDC42BPA 1q42.11 CDC42 binding protein kinase alpha (DMPK-like) LOC343363 1q42.13 similar to basic transcription factor 3 LOC391171 1 similar to beta-tubulin 4Q LOC255208 1q42.13 HSA1q42.3 beta-tubulin 4Q pseudogene MGC42493 1q42.13 hypothetical protein MGC42493 MRP63P2 1q42.13 mitochondrial ribosomal protein 63 pseudogene 2 MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6162 102.24 946 - Erneux (1992), Nalaskowski (2006)
  • targeting to the cytoskeleton and endoplasmic reticulum
  • a nuclear export signal has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal
  • - - - - - - Nalaskowski (2006)
  • targeting to the cytoskeleton and endoplasmic reticulum
  • a nuclear export signal has evolved in the catalytic domain de novo
  • - - - - - - Nalaskowski (2006)
  • remarkable differences to its rat homologue in the N-terminal targeting domain
  • a nuclear export signal has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear export signal that has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal (Nalaskowski 2006)
  • HOMOLOGY
    Homologene
    FAMILY
  • inositol phosphokinase (IPK) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton
    text in the plasma membrane, cytoskeleton and in the endoplasmic reticulum
    basic FUNCTION
  • regulating inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5) P4
  • controls positive selection of T cells and modulates Erk activity (Wen 2004)
  • responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling
  • playing a potential role as direct INSP3 metabolizing enzyme and direct regulator of Ca2+ responses to extracellular signals
  • converting Ins(1,4,5)P3 to inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (Miller 2007)
  • inhibitor of store-operated Ca2+ channels and crucial regulators of B cell selection and activation (Miller 2007
  • possible function of ITPKA, ITPKB in differentiation of embryonic stem cells
  • dense tubular system protein, that is a major regulator of calcium homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by activated by calmodulin; form B is much more sensitive to calcium/calmodulin than form A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late onset Alzheimer disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS