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FLASH GENE
Symbol ITPKB contributors: mct/npt - updated : 14-11-2018
HGNC name inositol 1,4,5-trisphosphate 3-kinase B
HGNC id 6179
Location 1q42.12      Physical location : 226.819.391 - 226.926.876
Synonym name
  • IP3 3-kinase
  • proliferation-inducing protein 37
  • 1D-myo-inositol-trisphosphate 3-kinase B
    • Synonym symbol(s) IP3K, IP3KB, PIG37
    EC.number 2.7.1.127
    DNA
    TYPE functioning gene
    STRUCTURE 105.97 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D1S439 - ITPKB - D1S251 - D1S459 - D1S437 - D1S235 - D1S204 - D1S609 - D1S2682 - qter
    Authors White (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6162 102.24 946 - Erneux (1992), Nalaskowski (2006)
  • targeting to the cytoskeleton and endoplasmic reticulum
  • a nuclear export signal has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal
    • - - - - - - Nalaskowski (2006)
  • targeting to the cytoskeleton and endoplasmic reticulum
  • a nuclear export signal has evolved in the catalytic domain de novo
    • - - - - - - Nalaskowski (2006)
  • remarkable differences to its rat homologue in the N-terminal targeting domain
  • a nuclear export signal has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal
    • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear export signal that has evolved in the catalytic domain as a substitute for an earlier evolved corresponding N-terminal signal (Nalaskowski 2006)
    • HOMOLOGY
    Homologene
    FAMILY
  • inositol phosphokinase (IPK) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton
    text in the plasma membrane, cytoskeleton and in the endoplasmic reticulum
    basic FUNCTION
  • regulating inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5) P4
  • controls positive selection of T cells and modulates Erk activity (Wen 2004)
  • responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling
  • playing a potential role as direct INSP3 metabolizing enzyme and direct regulator of Ca2+ responses to extracellular signals
  • converting Ins(1,4,5)P3 to inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (Miller 2007)
  • inhibitor of store-operated Ca2+ channels and crucial regulators of B cell selection and activation (Miller 2007
  • possible function of ITPKA, ITPKB in differentiation of embryonic stem cells
  • dense tubular system protein, that is a major regulator of calcium homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by activated by calmodulin; form B is much more sensitive to calcium/calmodulin than form A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late onset Alzheimer disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS