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FLASH GENE
Symbol ITM2A contributors: mct/npt - updated : 07-01-2009
HGNC name integral membrane protein 2A
HGNC id 6173
Location Xq21.1      Physical location : 78.615.882 - 78.623.049
Synonym name
  • BRICHOS domain containing 2A
  • E25 protein
  • Synonym symbol(s) E25A, BRICD2A
    DNA
    TYPE functioning gene
    STRUCTURE 7.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - DXS1518 - DXS1447 - DXS6954 - DXS1420 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1874 29.7 263 - Ross (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage CD34+ hematopoietic stem/progenitor cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prokaryotic membrane lipoprotein lipid attachment site
  • transmembrane region
  • HOMOLOGY
    interspecies homolog to C.elegans c23h4.5
    Homologene
    FAMILY
  • ITM2 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • involved in osteo and chondrogenic differentiation
  • involved in transcriptional regulation of cartilage or bone specific gene
  • marker for early stages in endochondral ossification, and involved in the early stages of chondrogenesis (Van den Plas 2004)
  • enhancing myogenic differentiation (Van den Plas 2004)
  • BRICHOS domain-containing protein expressed preferentially in the T lineage among hematopoietic cells and is induced by MHC-mediated positive selection
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITM2A to be a target gene of GATA3, a T cell-specific transcription factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS