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FLASH GENE
Symbol ITM2A contributors: mct/npt - updated : 07-01-2009
HGNC name integral membrane protein 2A
HGNC id 6173
Location Xq21.1      Physical location : 78.615.882 - 78.623.049
Synonym name
  • BRICHOS domain containing 2A
  • E25 protein
    • Synonym symbol(s) E25A, BRICD2A
    DNA
    TYPE functioning gene
    STRUCTURE 7.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - DXS1518 - DXS1447 - DXS6954 - DXS1420 - qter
    Physical map
    KIAA2022 Xq13.2 KIAA2022 protein ABCB7 Xq13 ATP-binding cassette, sub-family B (MDR/TAP), member 7 MGC23937 Xq13.2 hypothetical protein MGC23937 similar to CG4798 LOC389875 X similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 ZDHHC15 Xq13.1 zinc finger, DHHC domain containing 15 BRAF2 Xq13.2 similar to v-raf murine sarcoma viral oncogene homolog B1 pseudogene LOC286495 Xq13.2 similar to Tetratricopeptide repeat protein 3 (TPR repeat protein D) HCA3 Xq13.2 hepatocellular carcinoma-associated protein HCA3 MGC874 Xq13.2 hypothetical protein MGC874 LDHBP Xq13.2-q13.3 lactate dehydrogenase B pseudogene KIAA1587 Xq13.2 hepatocellular carcinoma-associated protein HCA1 LOC392499 X similar to hypothetical protein FLJ13611 ATRX Xq13.3 alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) DKFZp564K142 Xq13.3 implantation-associated protein COX7B Xq13.1 cytochrome c oxidase subunit VIIb ATP7A Xq13.3 ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) PGK1 Xq13.3 phosphoglycerate kinase 1 TAF9L Xq13.1-q21.1 TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa CYSLTR1 Xq13-q21 cysteinyl leukotriene receptor 1 ZCCHC5 Xq13.3 zinc finger, CCHC domain containing 5 GPR23 Xq13-q21.1 G protein-coupled receptor 23 P2RY10 Xq21.1 purinergic receptor P2Y, G-protein coupled, 10 FKSG79 Xq13.3 putative purinergic receptor LOC347363 Xq13.3 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) ITM2A Xq13.3-q21.2 integral membrane protein 2A TBX22 Xq21.1 T-box 22 MGC26999 Xq21.1 hypothetical protein MGC26999 LOC347364 Xq21.1 similar to WW domain binding protein 11; Npw38-binding protein NpwBP; SH3 domain-binding protein SNP70 LOC286425 Xq21.1 similar to hexokinase 2; hexokinase-2, muscle FLJ38568 Xq21.1 hypothetical protein FLJ38568 LOC286426 Xq21.1 similar to Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) NSBP1 Xq13.3 nucleosomal binding protein 1 SH3BGRL Xq13.3 SH3 domain binding glutamic acid-rich protein like LOC392500 X similar to ribosomal protein L22 LOC266683 Xq13.3 dendritic cell protein pseudogene POU3F4 Xq21.1 POU domain, class 3, transcription factor 4 LOC158668 Xq21.1 similar to Telomeric repeat binding factor 1 (TTAGGG repeat binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1874 29.7 263 - Ross (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage CD34+ hematopoietic stem/progenitor cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prokaryotic membrane lipoprotein lipid attachment site
  • transmembrane region
    • HOMOLOGY
    interspecies homolog to C.elegans c23h4.5
    Homologene
    FAMILY
  • ITM2 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • involved in osteo and chondrogenic differentiation
  • involved in transcriptional regulation of cartilage or bone specific gene
  • marker for early stages in endochondral ossification, and involved in the early stages of chondrogenesis (Van den Plas 2004)
  • enhancing myogenic differentiation (Van den Plas 2004)
  • BRICHOS domain-containing protein expressed preferentially in the T lineage among hematopoietic cells and is induced by MHC-mediated positive selection
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITM2A to be a target gene of GATA3, a T cell-specific transcription factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS