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FLASH GENE
Symbol ITLN1 contributors: mct/npt - updated : 04-10-2012
HGNC name intelectin 1 (galactofuranose binding)
HGNC id 18259
Location 1q23.3      Physical location : 160.846.331 - 160.854.960
Synonym name
  • intestinal lactoferrin receptor
  • omentin 1
  • endothelial lectin HL-1
  • galactofuranose-binding lectin
  • Synonym symbol(s) LFR, FLJ20022, ITLN, HL1, HL-1, INTL, hIntL, omentin
    DNA
    TYPE functioning gene
    STRUCTURE 8.63 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLAMF6 1q23.1 SLAM family member 6 CD84 1q22-q23 CD84 antigen (leukocyte antigen) SLAMF1 1q21.3-1q23.2 signaling lymphocytic activation molecule family member 1 CD48 1q23 CD48 antigen (B-cell membrane protein) SLAMF7 1q23.1-q24.1 SLAM family member 7 LY9 1q21.3-q22 lymphocyte antigen 9 CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1209 - 313 - 2006 16531507
  • also called omentin1
  • major circulating isoform in human plasma
  • plasma omentin 1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance
  • omentin 1 gene expression were decreased with obesity and were highly correlated with each other in visceral adipose tissue
  • higher plasma omentin 1 levels were detected in lean subjects and in women compared with men
  • - - - - - - 2006 16531507
  • also called omentin 2, gene expression were decreased with obesity and were highly correlated with each other in visceral adipose tissue
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     stomach    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text small intestine
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , trimer
    HOMOLOGY
    interspecies homolog to murine intelectin
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text brush border membrane
    basic FUNCTION
  • adipokine playing a role in the recognition of bacteria-specific components in the host
  • adipokine expressed in omental adipose tissue in humans and may regulate insulin action
  • adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease
  • its loss may contribute to the development of insulin resistance and T2DM
  • potent insulin-sensitizing adipokine, and serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes
  • adipocytokine with insulin-sensitizing effect
  • plays an anti-inflammatory role by preventing the TNF1-induced COX2 expression in vascular endothelial cells
  • anti-inflammatory in vascular endothelial cells
  • may inhibit TNF-induced expression of adhesion molecules in endothelial cells via blocking ERK/NFKB1 pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • omentin inhibited TNF-activated signal pathway of NFKB1 by preventing NFKB1 inhibitory protein (NFKBIA) degradation and NFKB1/DNA binding activity
  • ITLN1 inhibition of TNF-induced expression of VCAM1 and ICAM1 is mediated by its down-regulation of ERK/NFKB signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    associated with increasing obesity and insulin resistance
    constitutional     --low  
    by insulin and glucose (explain the decreased omentin-1 levels observed in overweight women with PCOS (Tan 2008)
    constitutional     --low  
    decreases in the overweight and obese human subjects
    constitutional     --low  
    found in many chronic inflammatory diseases
    constitutional     --low  
    in patients with acute coronary syndrome (ACS) and stable angina pectoris compared with controls
    constitutional     --over  
    SERPINA12 and ITLN1 are up-regulated in large for gestational age infants at term
    Susceptibility to obesity with insulin resistance
    Variant & Polymorphism SNP single nucleotide missense polymorphism Val109Asp associated with type 2 diabetes mellitus or chronic inflammatory bowel diseases
    Candidate gene omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    may be a potential drug target against the obesity and/or type II diabetes-related vascular diseases
    ANIMAL & CELL MODELS