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FLASH GENE
Symbol ITIH3 contributors: mct/npt - updated : 18-11-2009
HGNC name inter-alpha (globulin) inhibitor H3
HGNC id 6168
Location 3p21.1      Physical location : 52.828.783 - 52.843.025
Synonym name
  • inter-alpha- (protein HC), heavy chain 3
  • inter-alpha-trypsin inhibitor heavy chain H3
  • serum-derived hyaluronan-associated protein
  • pre-alpha (globulin) inhibitor, H3 polypeptide
  • ITI heavy chain H3
    • Synonym symbol(s) H3P, SHAP
    DNA
    TYPE functioning gene
    STRUCTURE 14.24 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure a tripartite complex including CREB-2 and two molecules of the gut-enriched, Kruppel-like factor cooperate to bind to an upstream area whose 3' end overlaps the Sp1-binding sites
    MAPPING cloned Y linked   status confirmed
    Map pter - ITIH1 - ITIH3 - ITIH4 - cen
    Authors Diarra-Mehrpour (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3037 - 890 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus    
     liver   highly
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA domain
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • trypsin inhibitor
  • regulaing the localization, synthesis and
    • degradation of hyaluronan which are essential to cells undergoing biological processes
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --low  
    in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)
    Susceptibility
  • to myocardial infarction
  • to bipolar disorder
    • Variant & Polymorphism SNP significant association between myocardial infarction and a SNP in exon 2
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS