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FLASH GENE
Symbol ITIH2 contributors: npt/ - updated : 21-06-2006
HGNC name inter-alpha (globulin) inhibitor H2
HGNC id 6167
Location 10p14      Physical location : 7.745.235 - 7.791.482
Synonym name
  • serum-derived hyaluronan-associated protein
  • inter-alpha-(protein HC), heavy chain 2
  • inter-alpha (globulin) inhibitor, H2 polypeptide
  • ITI heavy chain H2
  • Synonym symbol(s) H2P, SHAP, IGHEP2
    DNA
    TYPE functioning gene
    STRUCTURE 46.25 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ASB13 10p15.1 ankyrin repeat and SOCS box-containing 13 FLJ20360 10p15.1 hypothetical protein FLJ20360 GDI2 10p15 GDP dissociation inhibitor 2 ANKRD16 10p15.1 ankyrin repeat domain 16 FBXO18 10p15.1 F-box only protein, helicase, 18 IL15RA 10p15-p14 interleukin 15 receptor, alpha IL2RA 10p15-p14 interleukin 2 receptor, alpha SPF45 LOC387633 10 LOC387633 LOC142937 10p15.1 hypothetical protein BC008131 PFKFB3 10p15-p14 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PRKCQ 10p15 protein kinase C, theta SFMBT2 10p15.1 Scm-related gene containing four mbt domains 2 FLJ14641 10p15.1 hypothetical protein FLJ14641 ITIH5 10p15.1 inter-alpha (globulin) inhibitor H5 ITIH2 10p15 inter-alpha (globulin) inhibitor, H2 polypeptide KIN 10p15-p14 KIN, antigenic determinant of recA protein homolog (mouse) ATP5C1 10q22-q23 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 TAF3 10p15.1 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa GATA3 10p15 GATA binding protein 3 LOC389935 10 similar to hypothetical protein FLJ14936 LOC220959 10p15.1 similar to KRT8 protein LOC338591 10p15.1 similar to hypothetical protein FLJ20420 LOC389936 10 similar to proline-rich proteoglycan 2 LOC389937 10 similar to heat shock protein 90 beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3198 - 946 - Zhuo (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • trypsin inhibitor, acting as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein
  • potentiate the interaction by increasing the avidity of hyaluronan to CD44 and altering their distribution on cell surfaces (Zhuo 2006)
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --low  
    in 70 p 100 of breast cancer (Hamm 2008)
    tumoral     --low  
    in multiple human solid tumors (Hamm 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS