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FLASH GENE
Symbol ITGB8 contributors: - updated : 26-04-2005
HGNC name integrin, beta 8
HGNC id 6163
Location 7p21.1      Physical location : 20.370.724 - 20.455.378
DNA
TYPE functioning gene
STRUCTURE 79.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC392639 7 similar to TWIST neighbor MGC42090 7p21.1 hypothetical protein MGC42090 COL1A2 7q21.3 collagen, type I, alpha 2 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 CAS1 7q21.3 O-acetyltransferase RPL21 13pter-p13 ribosomal protein L21 SGCE 7q21.3 sarcoglycan, epsilon TWISTNB 7p21 TWIST neighbor MGC42090 7p21.1 hypothetical protein MGC42090 PEG10 7q21 paternally expressed 10 7A5 7p15.3 putative binding protein 7a5 LOC392955 7 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC392956 7 similar to dJ133P16.1 (ADP-ribosylation factor 1) ITGB8 7p integrin, beta 8 PPP1R9A 7q21 protein phosphatase 1, regulatory (inhibitor) subunit 9A TM4SF12 7 transmembrane 4 superfamily member 12 7A5 7p15.3 putative binding protein 7a5 LOC392870 7 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati ING3 7q31 inhibitor of growth family, member 3 ABCB5 7p14 ATP-binding cassette, sub-family B (MDR/TAP), member 5 FLJ21986 7q31.32 hypothetical protein FLJ21986 ITGB8 7p integrin, beta 8 PON1 7q21.3 paraoxonase 1 SP8 7p21.2 Sp8 transcription factor PON3 7q21.3 paraoxonase 3 LOC392640 7 similar to ribosomal protein L23 PON2 7q21.3 paraoxonase 2 LOC392003 7 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati ASB4 7q21-q22 ankyrin repeat and SOCS box-containing 4 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C ABCB5 7p14 ATP-binding cassette, sub-family B (MDR/TAP), member 5 PDK4 7q21.3 pyruvate dehydrogenase kinase, isoenzyme 4 LOC392749 7 LOC392749 LOC392978 7 similar to Cytochrome c, somatic LOC392979 7 similar to ribosomal protein L18; 60S ribosomal protein L18 SP8 7p21.2 Sp8 transcription factor LOC222901 7p15.3 similar to ribosomal protein L23 LOC392871 7 similar to argininosuccinate synthetase DNCI1 7q21.3 dynein, cytoplasmic, intermediate polypeptide 1 SP4 7p15.2-p14 Sp4 transcription factor PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 DNAH11 7p15 dynein, axonemal, heavy polypeptide 11 SLC25A13 7q21.3 solute carrier family 25, member 13 (citrin) LOC340274 7p15.3 similar to argininosuccinate synthetase AASS 7q31.3 aminoadipate-semialdehyde synthase RNU1P8 7p15.3 RNA, U1 small nuclear pseudogene 8
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Reproductivefemale systembreastmammary gland  
 female systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal protein
  • a globular domain
  • a stalk region with four EGF-like repeats each with eight cysteine residues
  • VWFA-like domain
  • a single transmembrane domain (1TM)
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Itgb8
    Homologene
    FAMILY integrin beta chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION
    text type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGAV in fibronectin, VCAM1 receptors (tail)
    INTERACTION
    DNA
    RNA
    small molecule
    protein ITGAV,VCAM1 receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS