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FLASH GENE
Symbol ITGB7 contributors: mlc - updated : 19-12-2007
HGNC name integrin, beta 7
HGNC id 6162
Location 12q13.13      Physical location : 53.585.107 - 53.601.000
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D12S270 - D12S262 - (D12S803 ,D12S390 ,KRT6B ) - KRT6A - D12S760 - (KRT5 ,D12S766 ) - D12S1533 - KRT2A - D12S1547 - KRT1 - D12S96 - (KRT4 ,D12S398 ) - KRT18 - KRT8 - ITGB7 - RARG - (D12S1190E - D12S359 ) - MAP3K12 - D12S1276 - D12S884 - D12S887 - D12S881 - D12S19 - (D12S886 - D12S325 ,D12S1651 ,D12S1586 ) - (HOXC5 ,D12S103 ) - D12S312 - D12S1194E - D12S1994 - D12S1707 - qter
Authors 4st Workshop chrom.12 (97)
Physical map
K6IRS2 12q13.13 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 K6IRS3 12q13.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 KRT2A 12q13.1-q13.2 keratin 2A (epidermal ichthyosis bullosa of Siemens) KRT1 12q13 keratin 1 (epidermolytic hyperkeratosis) LOC387860 12 similar to keratin 1b LOC341409 12q13.13 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 LOC387861 12 similar to K+ channel tetramerization protein HUMCYT2A 12q13.13 cytokeratin 2 KRT3 12q13 keratin 3 KRT4 12q13 keratin 4 KRT6L 12q13.13 keratin 6L K5B 12q13.13 keratin 5b KRT8 12q13 keratin 8 KRT18 12q13 keratin 18 EIF4B 12q13.13 eukaryotic translation initiation factor 4B PRO1843 12q13.13 hypothetical protein PRO1843 TENC1 12q12 tensin like C1 domain-containing phosphatase FLJ14800 12q13.13 hypothetical protein FLJ14800 IGFBP6 12q13 insulin-like growth factor binding protein 6 SOAT2 12q13.13 sterol O-acyltransferase 2 LOC387862 12 hypothetical gene supported by AK130082; NM_001416 CSAD 12q13.11-q14.3 cysteine sulfinic acid decarboxylase LOC390316 12 similar to oriLyt TD-element binding protein 7 ITGB7 12q13.2 integrin, beta 7 MGC11308 12q13.13 hypothetical protein MGC11308 ESPL1 8 extra spindle poles like 1 (S. cerevisiae) PFDN5 12q13.1 prefoldin 5 C12orf10 12q13 chromosome 12 open reading frame 10 AAAS 12q13 achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) SP7 12q12 Sp7 transcription factor SP1 12q13.1 Sp1 transcription factor AMHR2 12q13 anti-Mullerian hormone receptor, type II DKFZP564J157 12q12 DKFZp564J157 protein PCBP2 12q13.12-q13.13 poly(rC) binding protein 2 MAP3K12 12q13 mitogen-activated protein kinase kinase kinase 12 TARBP2 12q12-q13 TAR (HIV) RNA binding protein 2 NPFF 12q13.13 neuropeptide FF-amide peptide precursor FLJ30317 12q13.13 hypothetical protein FLJ30317 ATF7 12q13 activating transcription factor 7 LOC341412 12q13.13 similar to ribosomal protein L31 ATP5G2 12q13.13 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2798 - 798 - Monteiro (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal protein,
  • a globular domain
  • a stalk region with four EGF-like repeats each with eight cysteine residues
  • a single transmembrane (TM) domain
  • a cytoplasmic tail
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGAV in fibronectin, VCAM1 receptors
    INTERACTION
    DNA
    RNA
    small molecule
    protein ITGAV, VCAM1 receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS