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FLASH GENE
Symbol ITGB7 contributors: mlc - updated : 19-12-2007
HGNC name integrin, beta 7
HGNC id 6162
Location 12q13.13      Physical location : 53.585.107 - 53.601.000
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D12S270 - D12S262 - (D12S803 ,D12S390 ,KRT6B ) - KRT6A - D12S760 - (KRT5 ,D12S766 ) - D12S1533 - KRT2A - D12S1547 - KRT1 - D12S96 - (KRT4 ,D12S398 ) - KRT18 - KRT8 - ITGB7 - RARG - (D12S1190E - D12S359 ) - MAP3K12 - D12S1276 - D12S884 - D12S887 - D12S881 - D12S19 - (D12S886 - D12S325 ,D12S1651 ,D12S1586 ) - (HOXC5 ,D12S103 ) - D12S312 - D12S1194E - D12S1994 - D12S1707 - qter
Authors 4st Workshop chrom.12 (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2798 - 798 - Monteiro (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal protein,
  • a globular domain
  • a stalk region with four EGF-like repeats each with eight cysteine residues
  • a single transmembrane (TM) domain
  • a cytoplasmic tail
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGAV in fibronectin, VCAM1 receptors
    INTERACTION
    DNA
    RNA
    small molecule
    protein ITGAV, VCAM1 receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS