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FLASH GENE
Symbol ITGB1BP3 contributors: npt/SGE - updated : 04-02-2010
HGNC name integrin beta 1 binding protein 3
HGNC id 17871
Location 19p13.3      Physical location : 3.933.100 - 3.942.412
Synonym name
  • muscle-specific beta 1 integrin binding protein
  • ribosylnicotinic acid kinase 2
  • NmR-K 2
  • Nicotinamide riboside kinase 2
  • Ribosylnicotinamide kinase 2
  • Muscle integrin-binding protein
    • Synonym symbol(s) MIBP, NRK2, MGC126624, RNK2
    EC.number 2.7.1.22
    DNA
    TYPE functioning gene
    STRUCTURE 9.31 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 775 20 186 - Bieganowski (2004)
    ATP/GTP-binding site motif A (P-loop)
    8 splicing 1142 26 230 - Li (1999)
  • also called variant 2 or NRK2
  • bipartite nuclear localization signal
  • ATP/GTP-binding site motif A (P-loop)
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Itgb1bp3 (85.1pc)
    Homologene
    FAMILY
  • uridine kinase family
  • NRK subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • reducing laminin matrix deposition and cell adhesion to laminin, but not to fibronectin
  • involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation
  • may play a role in the regulation of terminal myogenesis
  • catalyzing the phosphorylation of nicotinamide riboside NR and NaR to form NMN and NaMN
  • may play a rol ein the regulation of terminal myogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor , purine/pyrimidine
    signaling
  • Preiss-Handler independent NAD biosynthesis
  • pyridine nucleotide biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP binding
  • Mg2+ binding
    • protein
  • ITGB1 (alone or when associated with alpha-7)
    • cell & other
    REGULATION
    Other down-regulated during myoblast differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS