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FLASH GENE
Symbol ITGB1BP3 contributors: npt/SGE - updated : 04-02-2010
HGNC name integrin beta 1 binding protein 3
HGNC id 17871
Location 19p13.3      Physical location : 3.933.100 - 3.942.412
Synonym name
  • muscle-specific beta 1 integrin binding protein
  • ribosylnicotinic acid kinase 2
  • NmR-K 2
  • Nicotinamide riboside kinase 2
  • Ribosylnicotinamide kinase 2
  • Muscle integrin-binding protein
    • Synonym symbol(s) MIBP, NRK2, MGC126624, RNK2
    EC.number 2.7.1.22
    DNA
    TYPE functioning gene
    STRUCTURE 9.31 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    NFIC 19p13.3 nuclear factor I/C (CCAAT-binding transcription factor) LOC284422 19p13.3 similar to HSPC323 MGC4293 19p13.3 hypothetical protein MGC4293 FZR1 19p13.3 hypothetical protein MGC4293 LOC388492 19 LOC388492 MGC20700 19p13.3 hypothetical protein MGC20700 HMG20B 19p13.3 high-mobility group 20B GIPC3 19p13.3 PDZ domain protein GIPC3 LOC388493 19 similar to putative protein (5J182) TBXA2R 19p13.3 thromboxane A2 receptor PIP5K1C 19p13.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma TJP3 19p13.3 tight junction protein 3 (zona occludens 3) APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 775 20 186 - Bieganowski (2004)
    ATP/GTP-binding site motif A (P-loop)
    8 splicing 1142 26 230 - Li (1999)
  • also called variant 2 or NRK2
  • bipartite nuclear localization signal
  • ATP/GTP-binding site motif A (P-loop)
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Itgb1bp3 (85.1pc)
    Homologene
    FAMILY
  • uridine kinase family
  • NRK subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • reducing laminin matrix deposition and cell adhesion to laminin, but not to fibronectin
  • involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation
  • may play a role in the regulation of terminal myogenesis
  • catalyzing the phosphorylation of nicotinamide riboside NR and NaR to form NMN and NaMN
  • may play a rol ein the regulation of terminal myogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor , purine/pyrimidine
    signaling
  • Preiss-Handler independent NAD biosynthesis
  • pyridine nucleotide biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP binding
  • Mg2+ binding
    • protein
  • ITGB1 (alone or when associated with alpha-7)
    • cell & other
    REGULATION
    Other down-regulated during myoblast differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS