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FLASH GENE
Symbol ITGAX contributors: mct/npt - updated : 30-04-2010
HGNC name integrin, alpha X (complement component 3 receptor 4 subunit)
HGNC id 6152
Location 16p11.2      Physical location : 31.366.508 - 31.394.318
Synonym name
  • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
  • cell differentiation antigen CD11c (gp150/95),150/95kD
  • LFA1 complex, alpha chain, identified by antibodies S-HCL3, B-ly6, L29, BL-4H4
  • myeloid membrane antigen, alpha subunit
  • p150 95 integrin alpha chain
  • leu M5, alpha subunit
  • CD11 antigen-like family member C
  • leukocyte adhesion glycoprotein p150,95 alpha chain
  • Synonym symbol(s) CD11C, CR4, SLEB6, Leu M5
    DNA
    TYPE functioning gene
    STRUCTURE 27.81 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390690 16 similar to Protein C20orf27 BCL7C 16p11 B-cell CLL/lymphoma 7C CTF1 16p11.2-p11.1 cardiotrophin 1 LOC283932 16p11.2 hypothetical protein LOC283932 MGC13024 16p11.2 hypothetical protein MGC13024 KIAA0339 16p11 hypothetical protein MGC13024 HSD3B7 16p11.2-12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 STX1B2 16p12-p11 syntaxin 1B2 STX4A 16p13.13-p12.3 syntaxin 4A (placental) FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200 BCKDK 16p11.2 branched chain alpha-ketoacid dehydrogenase kinase MYST1 16p11.2 MYST histone acetyltransferase 1 PRSS8 16p11.2 protease, serine, 8 (prostasin) FLJ90661 16p11.2 hypothetical protein FLJ90661 LOC390691 16 similar to Filamin B (FLN-B) (Beta-filamin) (Actin-binding like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1) FUS 16p11.2 fusion, derived from t(12;16) malignant liposarcoma ASC 16p12-p11.2 fusion, derived from t(12;16) malignant liposarcoma PYC1 16p11.2 pyrin-domain containing protein 1 ITGAM 16p11.2 integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) ITGAX 16p11.2 integrin, alpha X (antigen CD11C (p150), alpha polypeptide) COX6A2 16p12-p11 cytochrome c oxidase subunit VIa polypeptide 2 MGC46336 16p11.2 hypothetical protein MGC46336 FLJ13063 16p11.2 hypothetical protein FLJ13063 TGFB1I1 16p11 transforming growth factor beta 1 induced transcript 1 SLC5A2 16p11.2 solute carrier family 5 (sodium/glucose cotransporter), member 2 FLJ13868 16p11.2 hypothetical protein FLJ13868 ERAF 16p11.1 erythroid associated factor LOC388247 16 similar to cold shock domain protein A; Cold-shock domain protein A LOC342426 16p11.2 similar to zinc finger protein 267; zinc finger (C2H2) MGC3020 16p11.2 hypothetical protein MGC3020 LOC124411 16p11.2 hypothetical protein LOC124411 VN1R3 16p11.2 vomeronasal 1 receptor 3 LOC390692 16 similar to hypothetical protein FLJ10290 ZNF267 16p11.1 zinc finger protein 267
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 4666 - 1163 - Wu (2010)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage myeloid cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain with a sevenfold repeated structure
  • putative cation-binding motifs in the three of four C terminal repeats
  • an I domain (UWF type A domain) inserted between the second and third repeats ligand binding, connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • beta(2)-integrin that plays an important role in T-cell accumulation and activation in adipose tissue, and contributes to insulin resistance associated with obesity (Wu 2010)
  • differential involvement of ITGAX and ITGAM in adhesion and subsequent cytoskeletal changes in monocytes exposed to different conditions indicates the importance of each integrin in distinct responses during inflammation (Georgakopoulos 2008)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text phagocytosis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • dimerizing with ITGB2 in fibrinogen,receptor
  • forming with ITGB2 a leukocyte-specific integrin referred to i(C3b) receptor 4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by the proliferative state of the cell and tightly coupled to progression along the myeloid diferentiation pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus (SLE)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS