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FLASH GENE
Symbol ITGAE contributors: npt/mct - updated : 07-02-2009
HGNC name integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
HGNC id 6147
Location 17p13.3      Physical location : 3.617.919 - 3.704.537
Synonym name
  • CD103 antigen
  • integrin alpha E precursor
  • antigen CD103, human mucosal lymphocyte antigen 1
  • integrin alpha-IEL
  • alphaEbeta7 integrin
  • Synonym symbol(s) CD103, HUMINAE, MGC141996
    DNA
    TYPE like-sequence
    STRUCTURE 86.62 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked   status provisional
    Map pter - D17S661 - D17S683 - ITGAE - D17S1575 - D17S1576 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 3878 130.1 1179 - Schlickum (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a binding site for EED mapped to a short membrane-proximal region of the beta7 cytoplasmic tail with Tyr-735 being of critical importance
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • contribute to lymphocyte homing and to the development of protective or autoreactive immune responses at mucosal sites (Rietzler 1998)
  • not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes (Schlickum 2008)
  • marker for alloantigen-induced regulatory CD8+ T cells (Uss 2006)
  • its expression on dendritic cells influences the balance between effector and regulatory T cell activity in the intestine (Annacker 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • Ca2+
  • protein interaction with EED (interacts with the integrin beta7 cytoplasmic tail)(Rietzler 1998)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS