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FLASH GENE
Symbol ITGA9 contributors: SGE - updated : 30-07-2010
HGNC name integrin, alpha 9
HGNC id 6145
Location 3p22.2      Physical location : 37.493.812 - 37.861.279
Synonym name
  • integrin, alpha 4-like
  • integrin alpha-RLC
  • Synonym symbol(s) RLC, ITGA4L, ALPHA-RLC
    DNA
    TYPE functioning gene
    STRUCTURE 367.50 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D3S1609 - D3S1619 - D3S1612 - MLH1 - D3S3623 - ITGA9 - D3S1260 - cen
    Authors GeneMap (98)
    Physical map
    STAC 3p22.3 src homology three (SH3) and cysteine rich domain LOC205655 3p22.1 similar to hypothetical protein MGC8902 KIAA1765 3p22.1 KIAA1765 protein KIAA0342 3p24.2-p23 KIAA1765 protein LOC389106 3 LOC389106 LOC389107 3 similar to Hsp70/Hsp90 organizing protein homolog CG2720-PA LOC389108 3 LOC389108 LOC391527 3 similar to chromosome 2 open reading frame 7 EPM2AIP1 3p22.1 EPM2A (laforin) interacting protein 1 MLH1 3p21.3 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae) ACVR2B 3p22 activin A receptor, type IIB ENDOGL1 3p21.3 endonuclease G-like 1 LOC391528 3 similar to ribosomal protein L18a; 60S ribosomal protein L18a
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3962 112 1035 - Palmer (1993)
  • precursor
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularsmooth   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines other cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven FG-GAP repeats
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Itga9 (89.5pc)
    homolog to rattus Itga9 (90.0pc)
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION
    text type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • allows retinal pigmented epithelial cells adhesion on Bruch's membrane in wet age-related macular degeneration (Afshari 2010)
  • can induce and localise to focal adhesions in a high activation state, whereas its intermediate activity state normally supports cell adhesion consistent with migration (Lydolph 2009)
  • contributing to adhesion and differentiation of hematopoietic stem and progenitor cells in the endosteal stem cell niche (Schreiber 2009)
  • critical intrinsic regulator that controls the development of autoimmune arthritis (Kanayama 2009)
  • involved in the attraction of neutrophils via its binding to osteopontin (Nishimichi 2009)
  • receptor for nerve growth factor, brain-derived neutrophic factor and NT3 (Staniszewska 2008)
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein EMILIN1 is a novel ligand for keratinocyte ITGA9, suggesting prospective roles for this receptor-ligand pair in skin homeostasis
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    homozygously deleted in a lung cancer cell-line (Hibi 1994)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is required for fibronectin matrix assembly during lymphatic valve morphogenesis, implicating it as a candidate gene for primary lymphedema caused by valve defects (Bazigou 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS