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FLASH GENE
Symbol ITGA9 contributors: SGE - updated : 30-07-2010
HGNC name integrin, alpha 9
HGNC id 6145
Location 3p22.2      Physical location : 37.493.812 - 37.861.279
Synonym name
  • integrin, alpha 4-like
  • integrin alpha-RLC
  • Synonym symbol(s) RLC, ITGA4L, ALPHA-RLC
    DNA
    TYPE functioning gene
    STRUCTURE 367.50 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D3S1609 - D3S1619 - D3S1612 - MLH1 - D3S3623 - ITGA9 - D3S1260 - cen
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3962 112 1035 - Palmer (1993)
  • precursor
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularsmooth   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines other cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven FG-GAP repeats
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Itga9 (89.5pc)
    homolog to rattus Itga9 (90.0pc)
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION
    text type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • allows retinal pigmented epithelial cells adhesion on Bruch's membrane in wet age-related macular degeneration (Afshari 2010)
  • can induce and localise to focal adhesions in a high activation state, whereas its intermediate activity state normally supports cell adhesion consistent with migration (Lydolph 2009)
  • contributing to adhesion and differentiation of hematopoietic stem and progenitor cells in the endosteal stem cell niche (Schreiber 2009)
  • critical intrinsic regulator that controls the development of autoimmune arthritis (Kanayama 2009)
  • involved in the attraction of neutrophils via its binding to osteopontin (Nishimichi 2009)
  • receptor for nerve growth factor, brain-derived neutrophic factor and NT3 (Staniszewska 2008)
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein EMILIN1 is a novel ligand for keratinocyte ITGA9, suggesting prospective roles for this receptor-ligand pair in skin homeostasis
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    homozygously deleted in a lung cancer cell-line (Hibi 1994)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is required for fibronectin matrix assembly during lymphatic valve morphogenesis, implicating it as a candidate gene for primary lymphedema caused by valve defects (Bazigou 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS