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FLASH GENE
Symbol ITGA5 contributors: mct - updated : 20-05-2014
HGNC name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HGNC id 6141
Location 12q11-q13      Physical location : 54.789.046 - 54.813.050
Synonym name
  • cell differentiation antigen CD49E
  • very late activation protein 5, alpha subunit
  • Synonym symbol(s) CD49E, FNRA, VLA5A
    DNA
    TYPE functioning gene
    STRUCTURE 24.00 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    HOXC11 12q13.3 homeo box C11 HOXC10 12q13.3 homeo box C10 HOXC9 12q13.3 homeo box C9 HOXC8 12q13.3 homeo box C8 HOXC4 12q13.3 homeo box C4 HOXC6 12q13.3 homeo box C6 HOXC5 12q13.3 homeo box C5 LOC387863 12 LOC387863 SMUG1 12q13.11-q13.3 single-strand selective monofunctional uracil DNA glycosylase CBX5 12q12 chromobox homolog 5 (HP1 alpha homolog, Drosophila) HNRPA1 12q13.1 heterogeneous nuclear ribonucleoprotein A1 NFE2 12q13.1-q13.2 nuclear factor (erythroid-derived 2), 45kDa COPZ1 12q13.2-q13.3 coatomer protein complex, subunit zeta 1 GPR84 12q13.13 G protein-coupled receptor 84 ZNF385 12q13.13 zinc finger protein 385 ITGA5 12q11-q13 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) LOC387864 12 LOC387864 FLJ32942 12q13.13 hypothetical protein FLJ32942 HEM1 12q13.1 hematopoietic protein 1 PDE1B 12q13 phosphodiesterase 1B, calmodulin-dependent PPP1R1A 12q13.13 protein phosphatase 1, regulatory (inhibitor) subunit 1A LACRT 12q13 lacritin DCD 12q13.1 dermcidin
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain
  • a sevenfold repeated structure (7 FG-GAP repeats) with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • The extracellular domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • recognizes the sequence R-G-D in its ligands
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • an alpha chain and a beta chain
  • alpha 5 constituent of VLA-5 receptor
  • complexing with ITGB1 in fibronectin receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by DIDO1, inducing the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS