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FLASH GENE

Symbol

ITGA3

contributors: - updated : 21-05-2007

HGNC name	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
HGNC id	6139

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.33      Physical location : 48.133.339 - 48.167.848
Synonym name	cell differentiation antigen identified by monoclonal antibody J143
	antigen identified by monoclonal antibody J143
Synonym symbol(s)	CD49C, MSK18, GAPB3, VLA3A, VCA2

DNA

TYPE	functioning gene
STRUCTURE	34.00 kb     26 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ITGA3A - splicing 4637 ITGA3A 116.2 1051 . widely expressed . in heart, strongly expressed on vascular smooth muscle cells . isoforma A and B are both expressed on vascular smooth muscle cells Wits a 26 exons variant a 32 amino acids signal peptide (3.1 kDa) a 840 amino acids heavy chain mature peptide (93.4 kDa) a 176 amino acids light chain mature peptide (19.7 kDa) ITGA3B - splicing 4495 ITGA3B 118.7 1066 . expressed in brain and heart . isoforma A and B are both expressed on vascular smooth muscle cells Wits a 25 exons variant lacking exon 25 encoding for the longest product

EXPRESSION

Type

widely

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel       highly Digestive esophagus       moderately   intestine large intestine colon   moderately   liver       lowly   pharynx       moderately Endocrine pancreas       highly   thyroid       highly Nervous nerve       moderately Reproductive female system ovary     moderately   female system uterus     highly   male system prostate     highly Respiratory lung       moderately   respiratory tract larynx     moderately Urinary bladder       highly   kidney       highly Visual eye       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Epithelial barrier lining retinal pigment epithelium (RPE)   lowly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
	extracellular domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee ITGA3 (99.24 pc)
	homolog to rattus Itga3 (87.15 pc)
	homolog to murine Itga3 (86.26 pc)

Homologene

FAMILY

integrin alpha chain family

CATEGORY

adhesion , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

dimerizing with ITGB1 in fibronectin, laminin, collagen receptors

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS