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FLASH GENE
Symbol ITGA3 contributors: - updated : 21-05-2007
HGNC name integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
HGNC id 6139
Location 17q21.33      Physical location : 48.133.339 - 48.167.848
Synonym name
  • cell differentiation antigen identified by monoclonal antibody J143
  • antigen identified by monoclonal antibody J143
  • Synonym symbol(s) CD49C, MSK18, GAPB3, VLA3A, VCA2
    DNA
    TYPE functioning gene
    STRUCTURE 34.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 4637 116.2 1051 . widely expressed . in heart, strongly expressed on vascular smooth muscle cells . isoforma A and B are both expressed on vascular smooth muscle cells Wits
  • a 26 exons variant
  • a 32 amino acids signal peptide (3.1 kDa)
  • a 840 amino acids heavy chain mature peptide (93.4 kDa)
  • a 176 amino acids light chain mature peptide (19.7 kDa)
  • - splicing 4495 118.7 1066 . expressed in brain and heart . isoforma A and B are both expressed on vascular smooth muscle cells Wits
  • a 25 exons variant
  • lacking exon 25
  • encoding for the longest product
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   highly
    Digestiveesophagus   moderately
     intestinelarge intestinecolon moderately
     liver   lowly
     pharynx   moderately
    Endocrinepancreas   highly
     thyroid   highly
    Nervousnerve   moderately
    Reproductivefemale systemovary  moderately
     female systemuterus  highly
     male systemprostate  highly
    Respiratorylung   moderately
     respiratory tractlarynx  moderately
    Urinarybladder   highly
     kidney   highly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialbarrier liningretinal pigment epithelium (RPE) lowly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • extracellular domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee ITGA3 (99.24 pc)
    homolog to rattus Itga3 (87.15 pc)
    homolog to murine Itga3 (86.26 pc)
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component dimerizing with ITGB1 in fibronectin, laminin, collagen receptors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS