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Symbol ITGA2B contributors: mct/ - updated : 20-11-2018
HGNC name integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
HGNC id 6138
Corresponding disease
GT2 Glanzmann thrombasthenia
Location 17q21.31      Physical location : 42.449.549 - 42.466.873
Synonym name
  • platelet glycoprotein 2B
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)
  • antigen cell differentiation CD41, identified by antibodies CLB-thromb/7, P256, g6-5C3
  • CD41 antigen
  • Synonym symbol(s) CD41B, GP2B, GTA, CD41, HPA3, ITGAB, BDPLT16, BDPLT2, CD41B, PPP1R93
    TYPE functioning gene
    STRUCTURE 17.32 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure two important regulatory regions needed for the expression at high levels during megakaryopoiesis
    MAPPING cloned Y linked   status confirmed
    Physical map
    MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) RPIP8 17p13.2 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein FZD2 17q21.1 frizzled homolog 2 (Drosophila) FLJ35848 17q21.31 hypothetical protein FLJ35848 FLJ31795 17q21.31 hypothetical protein FLJ31795 DRF1 17q21.31 Dbf4-related factor 1 ADAM11 17q21.3 a disintegrin and metalloproteinase domain 11 GJA7 17q21.31 gap junction protein, alpha 7, 45kDa (connexin 45) CLST11240 17q21.31 CLST 11240 protein U5-116KD 17q21.31 U5 snRNP-specific protein, 116 kD LOC388389 17 similar to RIKEN cDNA 4933439F11 GFAP 17q21.1 glial fibrillary acidic protein LOC146909 17q21.31 hypothetical protein LOC146909 CRF 17q21 C1q-related factor FLJ22955 17q21.31 hypothetical protein FLJ22955 NMT1 17q21.32 N-myristoyltransferase 1 PLCD3 17q21 phospholipase C, delta 3 ACBD4 17q21.31 acyl-Coenzyme A binding domain containing 4
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 3334 - 1039 - 2018 29125375
    Type restricted
       expressed in (based on citations)
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats
  • proteolytically processed into disulfide linked heavy and light chains
  • the extracellular domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • collectively, ITGA2B /ITGB3 in mast cells plays an important part in fibrinogen (FB)-associated, chronic inflammation and innate immune responses
  • contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions
  • fibrinogen binding to the integrin ITGA2B, ITGB3 mediates platelet aggregation and spreading on fibrinogen-coated surfaces
  • platelets clearly support early steps in pulmonary metastasis via ITGA2B-dependent formation of platelet-tumor-aggregates, but at a later stage its absence is associated with an accelerated development of melanoma metastases
  • CELLULAR PROCESS cell communication
    a component
  • dimerizing with ITGB3 in fibrinogen, fibronectin, von Willebrand factor, vitronectin, thrombospondin receptors
    small molecule
  • target gene for FLI1
  • COL17A1
  • interaction between Trp110 of ITGA2B and Arg261 of ITGB3 is critical for ITGA2B/ITGB3 integrity and outside-in signaling-related functions
  • following commitment to megakaryocyte differentiation, the H3K27 demethylase KDM6B up-regulation influences both ITGA2B and MPL expression
  • PTK2B was rapidly phosphorylated and activated in platelets adherent to fibrinogen through integrin ITGA2B/ITGB3
  • deoxyribose-1-phosphate (dRP) is a novel autocrine amplifier of platelet activity, which acts on platelet redox levels and modulates ITGA2B/ITGB3
  • serine/threonine phosphatases regulate platelet ITGA2B/ITGB3 integrin receptor outside-in signaling mechanisms and clot retraction
  • FYB promotes integrin ITGA2B/ITGB3 activation in platelets, which lack SKAP1, suggesting an FYB integrin-regulatory pathway different from those in lymphocytes
  • WDR1 is essential for TLN1-induced activation of ITGA2B during platelet activation
  • cell & other
    corresponding disease(s) GT2
    related resource Glanzmann Thrombasthenia Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    specifically up regulated during megakaryopoiesis
    constitutional     --over  
    ITGA2B/ITGB3 is significantly higher in atopic myelitis (AM) patients than in controls as well as in females compared with males
    constitutional germinal mutation     gain of function
    activating mutations in ITGA2B and ITGB3 represent the etiology of a subset of congenital macrothrombocytopenias
    Variant & Polymorphism
    Candidate gene
  • ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma
  • ITGA2B/ITGB3 complex activation could be a putative prognostic biomarker for the rate of cognitive decline in Alzheimer patients
  • Therapy target
    ITGA2B/ITGB3 complex activation could be a potential new treatment target in Alzheimer patients