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FLASH GENE
Symbol ITGA1 contributors: mlc - updated : 07-05-2007
HGNC name integrin, alpha 1
HGNC id 6134
Location 5p11.1      Physical location : 52.084.135 - 52.249.484
Synonym name verylate activation protein 1
Synonym symbol(s) CD49A, MSK11, VLA1
DNA
TYPE functioning gene
STRUCTURE 167.00 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
MGC71745 5q11.2 similar to embigin LOC202319 5q11.2 similar to cyclophilin-LC; cyclophilin homolog overexpressed in liver cancer; chromosome 1 amplified sequence 2 FLJ21308 5q11.2 hypothetical protein FLJ21308 LOC153630 5q11.2 hypothetical LOC153630 LOC133569 5q11.2 similar to 40S ribosomal protein S10 ISL1 5q11.1 ISL1 transcription factor, LIM/homeodomain, (islet-1) PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveesophagus   moderately
 liver   moderately
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   predominantly
 spleen   highly
Nervousnerve   moderately
Reproductivefemale systemuteruscervix moderately
 female systembreastmammary gland moderately
 female systemplacenta  moderately
 female systemuterus  highly
Urinarykidney   highly
Visualeyeanterior segmentcornea lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   highly
Connectiveadipose  lowly
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period embryo
Text embryonic tissue at a lowly level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 28 amino acids signal peptide (3.0 kDa)
  • comprising a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats and an I domain inserted between the second and third repeats ligand binding. This domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • secondary structure an alpha and a beta subunit
    mono polymer heteromer , dimer
    isoforms Precursor a 1151 amino acids mature peptide (127.8 kDa)
    HOMOLOGY
    interspecies homolog to chimpanzee ITGA1 (99.58 pc)
    homolog to rattus Itga1 (87.86 pc)
    homolog to murine Itga1 (87.95 pc)
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell diffentiation antigen identified by monoclonal antibody SR84
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGB1 in collagen, laminin receptors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
  • activated in clear cell renal carcinomas with good outcome
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS