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FLASH GENE
Symbol ITFG1 contributors: - updated : 18-12-2006
HGNC name integrin alpha FG-GAP repeat containing 1
HGNC id 30697
Location 16q12.1      Physical location : 47.189.299 - 47.495.015
Synonym name
  • T-cell immunomodulatory protein
  • protein TIP
  • Synonym symbol(s) TIP, CDA08
    DNA
    TYPE functioning gene
    STRUCTURE 305.00 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   moderately
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  moderately
     male systemtestis  predominantly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one FG-GAP repeat domain
    conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Itfg1
    Homologene
    FAMILY TIP family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • secreted
  • type I membrane protein
  • basic FUNCTION
  • involved in cell-matrix adhesion
  • acting as a modulator of T-cell function
  • having a protective effect in graft versus host disease model
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component integrin complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS