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FLASH GENE

Symbol

ISL2

contributors: mct - updated : 23/12/2008

HGNC name	ISL LIM homeobox 2
HGNC id	18524

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24.3      Physical location : 76.629.146 - 76.634.816
Synonym name	ISL2 transcription factor, LIM/homeodomain, (islet-2)
Synonym symbol(s)	FLJ10160, ISL-2

DNA

TYPE	functioning gene
STRUCTURE	5.67 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 1836 isoform 1 - 359 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Visual ganglion cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	all tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-terminal LIM domains
	a conserved cysteine- and histidine-rich structure of two tandem repeated zinc fingers (LIM domain is involved in protein-protein interactions during transcriptional regulation)
	an homeodomain

secondary structure

HOMOLOGY

interspecies

homolog to rattus Isl2

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	transcription factor defining subclasses of motoneurons (that segregate into columns in the spinal cord and select distinct axon pathways)
	may be involved in both differentiation and maintenance of the tissues and might play an important role
	playing a prominent role in specifying retinal ganglion cell laterality

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

repressing ZIC2 for control of binocular vision

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS