Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ISG20 contributors: npt/ - updated : 18-07-2008
HGNC name interferon stimulated exonuclease gene 20kDa
HGNC id 6130
Location 15q26      Physical location : 89.182.038 - 89.198.879
Synonym name
  • interferon stimulated gene 20kDa
  • estrogen-regulated transcript 45 protein
  • promyelocytic leukemia nuclear body-associated protein ISG20
  • Synonym symbol(s) HEM45, CD25
    EC.number 3.1.13.1
    DNA
    TYPE functioning gene
    STRUCTURE 16.84 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 974 20.2 181 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus    
    Digestiveintestinelarge intestinecolon  
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lysine and arginine rich domain
  • coiled-coil structure bordered by potential phosphorylation sites
  • HOMOLOGY
    interspecies homolog to Xenopus XPMC2
    ortholog to murine Isg20
    Homologene
    FAMILY
  • exonuclease superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text colocalized with PML and SP100 gene products within the nuclear bodies
    basic FUNCTION
  • acting as an exonuclease
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PML
  • SP100
  • cell & other
    REGULATION
    induced by estrogen
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS