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FLASH GENE

Symbol

IRX4

contributors: mct - updated : 07-03-2013

HGNC name	iroquois homeobox protein 4
HGNC id	6129

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p15.33      Physical location : 1.877.540 - 1.882.880
Synonym symbol(s)	IRXA3

DNA

TYPE	functioning gene
STRUCTURE	5.34 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

close to IRX1 and IRX2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016358 5 - 2229 NP_057442 - 519 - 2001 11435706

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart ventricle       Homo sapiens Fetal   heart       specific Homo sapiens Adult Reproductive male system prostate     specific Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

homeodomain and a hexapeptide-like motif

HOMOLOGY

interspecies	homolog to murine Irx4
	homolog to C.elegans y54e5a.4

Homologene

FAMILY	tale/iro family of homeobox proteins
	Iroquois (Irx) homeodomain transcription factor gene family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	mediating ventricular differentiation during cardiac development
	had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	heart development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	involved in the regulation of SLIT1 expression, which is important for providing intermediate targets for retinal axons during their growth within the retina

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to prostate carcinoma (PC)

Variant & Polymorphism SNP	rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility (

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Irx4-deficient mice show ventricular dysfunction and develop cardiomyopathy