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FLASH GENE
Symbol IRX1 contributors: mct - updated : 03-11-2010
HGNC name iroquois homeobox 1
HGNC id 14358
Location 5p15.33      Physical location : 3.596.167 - 3.601.516
Synonym name
  • iroquois homeobox protein 1
  • iroquois-class homeodomain protein IRX-1
  • homeodomain protein IRXA1
    • Synonym symbol(s) IRX-5, IRXA1
    DNA
    TYPE functioning gene
    STRUCTURE 5.35 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located close to IRX2 and IRX4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1858 - 480 - 2002 12100884
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic developmental processes including anterior/posterior and dorsal/ventral patterning of specific regions of the central nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • homeodomain and a hexapeptide-like motif
    • HOMOLOGY
    interspecies homolog to murine Irx1
    homolog to C.elegans C06e4.2
    Homologene
    FAMILY
  • TALE/IRO homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiples roles during pattern formation of vertebrate embryos
  • with IRX3, are required for proper formation of the intermediate renal tubule
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    up-regulated in germ cells seminomas
    tumoral     --low  
    by hypermethylation in head and neck squamous cell carcinoma
    tumoral   LOH    
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could potentially serve as a biomarker for gastric cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-vasculogenic mimicry mechanisms, in addition to previously found cell growth and invasion
    ANIMAL & CELL MODELS