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FLASH GENE
Symbol IRS4 contributors: npt/ - updated : 23-05-2007
HGNC name insulin receptor substrate 4
HGNC id 6128
Location Xq22.3      Physical location : 107.975.726 - 107.979.607
Synonym name 160 kDa phosphotyrosine protein
Synonym symbol(s) IRS-4, PY160
DNA
TYPE functioning gene
STRUCTURE 3.94 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ10178 Xq22.3 hypothetical protein FLJ10178 RNF128 Xq22.3 ring finger protein 128 FLJ20298 Xq22.3 FLJ20298 protein LOC92129 Xq22.3 hypothetical protein BC007652 CLDN2 Xq22.3-23 claudin 2 ZCWCC2 Xq22.3 zinc finger, CW-type with coiled-coil domain 2 FLJ11016 Xq22.1-24 hypothetical protein FLJ11016 FLJ20130 Xq22.3 hypothetical protein FLJ20130 MGC35261 Xq22.3 hypothetical protein MGC35261 MYCL2 Xq22.1-q22.3 v-myc myelocytomatosis viral oncogene homolog 2 (avian) LOC392516 X similar to Keratin 18 KIAA1817 Xq22 KIAA1817 protein PRPS1 Xq22-q24 phosphoribosyl pyrophosphate synthetase 1 DSIPI Xq22.3 delta sleep inducing peptide, immunoreactor LOC392517 X similar to dJ820B18.1 (similar to nuclear cap binding protein) MID2 Xq22 midline 2 NOD13 Xq22.3 NOD13 pseudogene TEX13B Xq23 testis expressed sequence 13B MGC44287 Xq22.3 hypothetical protein MGC44287 PSMD10 Xq22.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 AUTL2 Xq22.1-q22.3 AUT-like 2, cysteine endopeptidase (S. cerevisiae) COL4A6 Xq22.3 collagen, type IV, alpha 6 COL4A5 Xq22.3 collagen, type IV, alpha 5 (Alport syndrome) IRS4 Xq22.3 insulin receptor substrate 4 LOC392519 X similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) GUCY2F Xq22 guanylate cyclase 2F, retinal NXT2 Xq22.3 nuclear transport factor 2-like export factor 2 LOC347537 Xq23 similar to mitofusin 1 isoform 1 KCNE1L Xq22.3 potassium voltage-gated channel, Isk-related family, member 1-like FACL4 Xq22.3-q23 fatty-acid-Coenzyme A ligase, long-chain 4 LOC392520 X similar to ribosomal protein S5 FLJ22679 Xq22.3 hypothetical protein FLJ22679 AMMECR1 Xq22.3 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 1 GNG5ps Xq23 G protein gamma 5-like subunit KIAA1318 Xq23 KIAA1318 protein NRLN1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3939 133.6 1257 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a phosphotyrosine binding (PTB) domain
  • twelve potential tyrosine phosphorylation sites in the C terminal region
  • HOMOLOGY
    interspecies ortholog to murine Irs4
    homolog to Drosophila chico
    Homologene
    FAMILY
  • IRS family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytoplasmic side of plasma membrane
    basic FUNCTION
  • mediating the biological response to insulin stimulation by binding and activating various enzymes or adaptor molecules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the SH2 domain of PIK3s and GRB2 proteins
  • INSR, IRAS
  • cell & other
    REGULATION
    activated by osmotic stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS