SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| IRGM translocates to mitochondria where it regulates autophagy in association with mitochondrial fission |
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basic FUNCTION
| playing a role in autophagy and in the reduction of intracellular bacillary load |
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plays a major role in maintaining T lymphocyte homeostasis during host IFN gamma responses by protecting these cells from autophagy-dependent cell death |
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play an important role in defense against intracellular pathogen Mycobacterium tuberculosis by regulating autophagy |
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playing a role in defense against intracellular pathogens |
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important role of the IRGM gene in autophagy and Crohn disease in response to pathogenesis |
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influenced mitochondrial membrane polarization and cell death |
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having a direct role in mitochondrial morphology, rather than functioning indirectly, through inhibition of autophagy or mitofusins |
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powerful negative regulator of IFN-dependent stimulation in hematopoietic stem cells, with an essential role in preserving hematopoietic stem cell number and function |
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