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FLASH GENE
Symbol IRF9 contributors: mct - updated : 21-08-2014
HGNC name interferon regulatory factor 9
HGNC id 6131
Location 14q11.2      Physical location : 24.630.421 - 24.635.772
Synonym name
  • interferon-stimulated transcription factor 3, gamma 48kDa
  • IFN-alpha-responsive transcription factor subunit
  • ISGF3 p48 subunit
  • Synonym symbol(s) ISGF3, ISGF3G, p48, IRF-9
    DNA
    TYPE functioning gene
    STRUCTURE 5.35 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D14S283 - TRD@ -TRA@ - PSMB5 - IRF9 - D14S264 -D14S1041 - D14S275 - cen
    Authors GeneMap (98)
    regionally located located close to the 2 genes for PA28 (PSME1 and PSME2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1699 43 393 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Isfg3g
    homolog to C.elegans R119.2
    intraspecies homolog to interferon regulatory factor and Myb family member of DNA binding proteins,highly
    Homologene
    FAMILY
  • IRF family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text cytoplasmic but translocated to the nucleus after activation
    basic FUNCTION
  • acting as the DNA recognition subunit
  • activating transcription in response to alpha interferon
  • is the key factor for eliciting the antiproliferative activity of IFN-alpha
  • inhibits the development of cardiac hypertrophy by suppressing the transcriptional activity of myocardin in the heart
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell surface receptor linked signal transduction
    a component
  • component of interferon stimulated transcription factor 3 gamma
  • STAT1, STAT2 associates with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as ISGF3
  • INTERACTION
    DNA binding to interferon-stimulated response element (or ISRE)
    RNA
    small molecule
    protein
  • nuclear transit of the intracellular domain of the interferon receptor subunit IFNAR2 requires STAT2 and IRF9
  • IRF1 and IRF9 are sequentially activated and recruited to the IL27 IFN-stimulated regulatory element site
  • interaction between STAT2 and IRF9
  • cell & other
    REGULATION
    induced by interferon alpha and interferon beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Irf9-deficient mice exhibited pronounced cardiac hypertrophy after pressure overload, as demonstrated by increased cardiomyocyte size, extensive fibrosis, reduced cardiac function