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FLASH GENE
Symbol IRF2BP2 contributors: mct/npt/pgu - updated : 18-05-2009
HGNC name interferon regulatory factor 2 binding protein 2
HGNC id 21729
Location 1q42.3      Physical location : 234.740.016 - 234.745.271
Synonym symbol(s) IRF-2BP2, DIF-1
DNA
TYPE functioning gene
STRUCTURE 5.26 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KIAA1383 1q42.2 KIAA1383 protein MGC13186 1q42.2 hypothetical protein MGC13186 FLJ11383 1q42.2 hypothetical protein FLJ11383 LOC148995 1q42.2 similar to 40S ribosomal protein S7 (S8) KIAA1804 1q42 mixed lineage kinase 4 KCNK1 1q42-q43 potassium channel, subfamily K, member 1 SLC35F3 1q42.3 solute carrier family 35, member F3 LOC148640 1q42.3 similar to ribosomal protein S15 LOC388753 1 similar to RIKEN cDNA 1810063B05 TARBP1 1q42.3 TAR (HIV) RNA binding protein 1 IRF2BP2 1q42.3 interferon regulatory factor 2 binding protein 2 LOC284527 1q42.3 hypothetical gene supported by BC016972 TOMM20 1q42 hypothetical gene supported by BC016972 KIAA0117 1q42.3 KIAA0117 protein RBP1L1 1q42.1-q43 retinoblastoma binding protein 1-like 1 GGPS1 1q43 geranylgeranyl diphosphate synthase 1 TBCE 1q42.3 tubulin-specific chaperone e MGC39558 1q42.3 hypothetical protein MGC39558 GNG4 1q42.3 guanine nucleotide binding protein (G protein), gamma 4 CHS1 1q42.1-q42.2 Chediak-Higashi syndrome 1 NID 1q43 nidogen (enactin) LOC343508 1q42.3 similar to aconitase 2 TM7SF1 1q42-q43 transmembrane 7 superfamily member 1 (upregulated in kidney) ERO1LB 1q42.2-q43 ERO1-like beta (S. cerevisiae) EDARADD 1q42.3 EDAR-associated death domain ENO1P 1q41-q42 enolase 1, (alpha) pseudogene LGALS8 1q42-q43 lectin, galactoside-binding, soluble, 8 (galectin 8) FLJ10359 1q42.3 protein BAP28
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4629 - 571 - 2003 12799427
2 - 4677 - 587 - 2003 12799427
EXPRESSION
Rna function high levels of IRF2BP2 mRNA in adult heart and skeletal muscles
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
Muscularstriatumskeletal lowly Homo sapiens
Muscularstriatumcardiac   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal zinc finger
  • a phosphorylation-dependent nuclear localization motif (
  • a C-terminal RING finger domain of the C3HC4 type
  • HOMOLOGY
    Homologene
    FAMILY
  • IRF2BP family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • found in the nucleus of cardiac and skeletal muscle cells (nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS)
  • basic FUNCTION
  • corepressor for IRF2
  • can inhibit both enhancer-ativated and basal transcription in an IRF2-dependent manner
  • might be part of a new feedback-loop for the cells after p53 activation, increasing the threshold for induction of apoptosis, but also inhibiting the progression of cell cycle, possibly to allow repair of damaged DNA
  • required to activate VEGFA expression
  • ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles
  • represses the NFATC2-dependent transactivation of NFAT-responsive promoters
  • negative regulator of the NFATC2 transcription factor, suggesting that NFATC2 repression occurs at the transcriptional level
  • muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IRF2
  • direct target gene of TP53, influencing the TP53-mediated cellular decision (promotes cell-cycle arrest and seems to interfere with TP53-mediated apoptosis after chemotherapeutic treatment)
  • cellular target of ITGB3BP, identified as a transcriptional repressor
  • interaction of IRF2BP2, IRF2BP1, and EAP1 occurs through the conserved C4 zinc fingers of these proteins, and forms DIF-1 complex
  • specifically interacts with the C-terminal domain of NFATC2 among the NFAT family members
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS