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FLASH GENE
Symbol IRF2 contributors: mct/npt - updated : 23-10-2015
HGNC name interferon regulatory factor 2
HGNC id 6117
Location 4q34.1-q35.1      Physical location : 185.308.877 - 185.395.726
Synonym symbol(s) IRF-2, DKFZp686F0244
DNA
TYPE functioning gene
STRUCTURE 86.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ30277 4q35.1 hypothetical protein FLJ30277 BOMB 4q35.1 BH3-only member B protein CLDN22 4pter-qter claudin 22 LOC391721 4 similar to Claudin-22 LOC389245 4 LOC389245 CARF 4q35.1 LOC389245 LOC389246 4 similar to vesicle-associated soluble NSF attachment protein receptor (v-SN; vesicle-associated soluble NSF attachment protein receptor (v-SNARE; homolog of S. cerevisiae VTI1) LOC389247 4 hypothetical gene supported by BC038563 ING1L 4q35.1 inhibitor of growth family, member 1-like MGC10198 4q35.1 hypothetical protein MGC10198 FLJ12716 4q35.1 FLJ12716 protein DKFZp762K222 4q35.1 hypothetical protein DKFZp762K222 ENPP6 4q35.1 ectonucleotide pyrophosphatase/phosphodiesterase 6 LOC391722 4 similar to myosin:SUBUNIT=regulatory light chain MGC24125 4q35.1 hypothetical protein MGC24125 IRF2 4q35.1 interferon regulatory factor 2 CASP3 4q35 caspase 3, apoptosis-related cysteine protease FLJ33167 4q35.1 hypothetical protein FLJ33167 KLIP1 4q35.1 KSHV latent nuclear antigen interacting protein 1 FACL2 4q34-q35 fatty-acid-Coenzyme A ligase, long-chain 2 LOC285435 4q35.1 hypothetical LOC285435 LOC391723 4 similar to Heslike SLC25A4 4q35 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 KIAA1430 4q35.1 KIAA1430 protein SNX25 4q35.1 sorting nexin 25 DKFZp761O0113 4q35.1 hypothetical protein DKFZp761O0113 Lrp2bp 4q35.1 low density lipoprotein receptor-related protein binding protein FLJ11200 4q35.1 hypothetical protein FLJ11200 MGC33607 4q35.1 hypothetical protein MGC33607 ALP LOC391724 4 similar to glycine-rich protein ARGBP2 4q35.1 similar to glycine-rich protein PRO0618 4q35.1 PRO0618 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2302 39.3 349 - Chae (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestine   highly
 mouth   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Epithelialsensoryolfactory  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ISRE (interferon stimulated response element)
  • a DNA binding domain at the N terminus (with tandem repeats)
  • a helix-hairpin-strand motif at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • IRF family
  • CATEGORY regulatory , transcription factor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • repressor of IRF1, functioning as a transcriptional activator of histone H4
  • regulates NFKB activity via the modulation of NFKB subcellular localization
  • involved in the initiation and progression of tumors
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to interferon stimulated response element (ISRE)
    RNA
    small molecule
    protein
  • IRF2/NFKB interaction may play a role in the contexts of tumorigenesis
  • interacting with MDM2 (Pettersson 2009)
  • IRF1 and IRF2 could bind to IFP35 promoter and upregulate endogenous IFP35 protein level
  • cell & other
    REGULATION
    induced by induced in IFN-stimulated cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to atopic dermatitis in japanese patients
  • to psoriasis (PSORS13)
  • Variant & Polymorphism SNP 921G/A SNP in exon 9 increasing the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS