basic FUNCTION
| central element in the early signal transduction of Toll/IL1R (TIR) upstream of IRAK1 |
|
required for various responses induced by IL-1R and Toll-like receptor signals |
|
required for the optimal transduction of IL1-induced signals, including the activation of IRAK1, NF-kappaB, and JNK, and the maximal induction of inflammatory cytokines |
|
plays a critical role in IL1 receptor (IL1R)/TLR7-mediated induction of inflammatory responses |
|
initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression |
|
plays an important role in innate and adaptive immune responses |
|
its kinase activity is required for IRAK4-dependent signaling in innate and adaptive immunity |
|
protein kinases that mediate signaling by Toll/IL1/Plant R (TIR) domain-containing receptors including the IL-1, IL-18, and Toll-like receptors (TLRs) |
|
its non-kinase functions are essential in cells, whereas the kinase activity of IRAK4 appears redundant with that of IRAK1 |
|
having a kinase activity that is critical for development of atherosclerosis |
|
has an ability to induce the degradation of IRAK1 in addition to its role as an activator of IRAK1 |
|
induce the degradation of IRAK1 in a proteosome-independent manner |
|
MYD88 and the associated kinases IRAK1 and IRAK4 are essential for activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) survival |
|
IRAK4 activation acts normally to regulate microglial activation status and influence amyloid homeostasis in the brain |
|
serine/threonine kinase that is a central adaptor protein in TLR signaling |
|
unexpected role of IRAK4, AKT1, and MTOR in the regulation of tolerance in human monocytes |
|
IRAK4 is recruited to the membrane-proximal adaptor MYD88 through death domain (DD) interactions, forming the oligomeric Myddosome and mediating NFKB1 activation |
|
in pericytes, MYD88 and IRAK4 are key regulators of 2 major injury responses: inflammatory and fibrogenic |
|
kinase activity of IRAK4 plays a critical role in signalling mediated by the TLRs |
|
mediates host defense against infections |
|
plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity increases susceptibility to bacterial infections and causes defects in TLR and IL1 ligand sensing |