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FLASH GENE
Symbol IRAK3 contributors: npt/pgu - updated : 09-06-2015
HGNC name interleukin-1 receptor-associated kinase 3
HGNC id 17020
Location 12q14.3      Physical location : 66.582.977 - 66.648.392
Synonym name
  • interleukin-1 receptor-associated kinase M
  • IL-1 receptor-associated kinase M
  • Synonym symbol(s) IRAK-M, ASRT5, FLJ13601
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 65.43 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ32949 12q14.1 hypothetical protein FLJ32949 LOC390338 12 similar to T-box transcription factor TBX20 TMEM5 12q14.1 transmembrane protein 5 LOC341315 12q14.1 similar to Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1) SRGAP1 12q13.13 SLIT-ROBO Rho GTPase activating protein 1 FLJ32549 12q14.1 hypothetical protein FLJ32549 LOC115749 12q14.1 hypothetical protein LOC115749 LOC390339 12 similar to 40S ribosomal protein S11 XPOT 12q14 exportin, tRNA (nuclear export receptor for tRNAs) TBK1 13q14.2-q14.3 TANK-binding kinase 1 RASSF3 12q14.1 Ras association (RalGDS/AF-6) domain family 3 GNS 12q14 glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) KIAA0984 12q13.13 glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) WIF1 12q13.13 WNT inhibitory factor 1 MAN1 12q14 WNT inhibitory factor 1 LOC253827 12q14.1 hypothetical protein LOC253827 LOC387865 12 LOC387865 LOC204010 12q14.2 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) HMGA2 12q14-q15 high mobility group AT-hook 2 LOC341321 12q14.2 similar to 60S ribosomal protein L21 MGC14817 12q14.2 hypothetical protein MGC14817 CGI-119 12q14.1-q15 CGI-119 protein IRAK3 12q13.13 interleukin-1 receptor-associated kinase 3 RBMS1P 12q14.2 RNA binding motif, single stranded interacting protein 1, pseudogene LOC387866 12 LOC387866 LOC390340 12 similar to IAP-associated factor VIAF1; phosducin-like 2 HELB 12q14.2 helicase (DNA) B GRIP1 12q14.1-q14.2 glutamate receptor interacting protein 1 HGT2 12q14.3 glutamate receptor interacting protein 1 TIP120A 12q14 glutamate receptor interacting protein 1 LOC390341 12 similar to nuclear localization signal containing protein deleted in Velo-Cardio-Facial syndrome DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8168 - 535 - 2002 12150927
    12 - 8351 - 596 - 2002 12150927
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal DEATH domain
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Irak3
    Homologene
    FAMILY
  • protein kinase superfamily
  • IRAK family
  • Ser/Thr family of protein kinases
  • Pelle subfamily
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in lipopolysaccharide signal transduction, negative regulator
  • TOLL-like receptor (TLR) signaling, preventing dissociation of IRAK1 and IRAK4 from MYD88 and the formation of IRAK/TRAF6 complexes
  • involved in the pathogenesis of early-onset persistent asthma
  • play a pivotal role in the process of 'endotoxin tolerance' in human monocytes
  • initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression
  • IRAK3 is an important target for CASP6 (neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IRAK3)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    contributing to endotoxin tolerance and innate immunity homeostasis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYD88, IRAK1, IRAK4
  • negative regulator of the Toll-like receptor/IL-1R pathways, master regulator of NF- kappa B and inflammation
  • IRAK2 plays a key role in the TLR9-mediated transcriptional regulation of IRAK3 expression by sustaining activation of PKD1 and NFKB1
  • cell & other
    REGULATION
    induced by in the presence of a PI3K inhibitor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    corresponding disease(s)
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism SNP increasing the risk of early-onset persistent asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS