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FLASH GENE
Symbol IRAK3 contributors: npt/pgu - updated : 09-06-2016
HGNC name interleukin-1 receptor-associated kinase 3
HGNC id 17020
Location 12q14.3      Physical location : 66.582.977 - 66.648.392
Synonym name
  • interleukin-1 receptor-associated kinase M
  • IL-1 receptor-associated kinase M
  • Synonym symbol(s) IRAK-M, ASRT5, FLJ13601
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 65.43 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8168 - 535 - 2002 12150927
    12 - 8351 - 596 - 2002 12150927
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal DEATH domain
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Irak3
    Homologene
    FAMILY
  • protein kinase superfamily
  • IRAK family
  • Ser/Thr family of protein kinases
  • Pelle subfamily
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in lipopolysaccharide signal transduction, negative regulator
  • TOLL-like receptor (TLR) signaling, preventing dissociation of IRAK1 and IRAK4 from MYD88 and the formation of IRAK/TRAF6 complexes
  • involved in the pathogenesis of early-onset persistent asthma
  • play a pivotal role in the process of 'endotoxin tolerance' in human monocytes
  • initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression
  • IRAK3 is an important target for CASP6 (neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IRAK3)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    contributing to endotoxin tolerance and innate immunity homeostasis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYD88, IRAK1, IRAK4
  • negative regulator of the Toll-like receptor/IL-1R pathways, master regulator of NF- kappa B and inflammation
  • IRAK2 plays a key role in the TLR9-mediated transcriptional regulation of IRAK3 expression by sustaining activation of PKD1 and NFKB1
  • cell & other
    REGULATION
    induced by in the presence of a PI3K inhibitor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    IRAK3 were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism
    Candidate gene
    Marker
  • detection of IRAK3 methylation would be helpful in the prediction of patients’ survival as well as the follow-up of patients in hepatocellular carcinoma
  • dysregulated levels of the IRAK3 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    IRAK3 were down-regulated in HCC (hepatocellular carcinoma)cell lines through promoter methylation
    Susceptibility to early-onset persistent asthma
    Variant & Polymorphism
    Candidate gene
    Marker
  • detection of IRAK3 methylation would be helpful in the prediction of patients’ survival as well as the follow-up of patients in hepatocellular carcinoma
  • dysregulated levels of the IRAK3 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    ANIMAL & CELL MODELS