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FLASH GENE
Symbol IRAK2 contributors: mct - updated : 08-06-2015
HGNC name interleukin-1 receptor-associated kinase 2
HGNC id 6113
Location 3p25.3      Physical location : 10.206.562 - 10.285.427
Synonym symbol(s) IRA2, MGC150550, IRAK-2
EC.number 2.7.1.-
DNA
TYPE functioning gene
STRUCTURE 78.87 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ22405 3p26 hypothetical protein FLJ22405 LOC151835 3p25.3 copine family member BRPF1 3p26-p25 bromodomain and PHD finger containing, 1 OGG1 3p26.2 8-oxoguanine DNA glycosylase CAMK1 3p25.2 calcium/calmodulin-dependent protein kinase I TADA3L 3p25.3 transcriptional adaptor 3 (NGG1 homolog, yeast)-like ARPC4 3p25.3-p24.1 actin related protein 2/3 complex, subunit 4, 20kDa LOC389093 3 similar to RIKEN cDNA 4833441J24 DKFZP434B103 MGC29784 3p25.3 hypothetical protein MGC29784 CIDE-3 3p25.3 cell death activator CIDE-3 GL009 3p25.2 hypothetical protein GL009 IL17RE 3p25.3 interleukin 17 receptor E IL17RC 3p25.3 interleukin 17 receptor C CRELD1 3p25.3 cysteine-rich with EGF-like domains 1 FLJ33674 3p25.3 hypothetical protein FLJ33674 LOC55831 3p25.3 30 kDa protein HCP10 3p25.3 cytochrome c, somatic pseudogene LOC389094 3 LOC389094 CICE 3p25.3 cell death-inducing CIDE-like effector pseudogene FANCD2 3p25.3 Fanconi anemia, complementation group D2 HCP11 3p25.3 cytochrome c, somatic pseudogene MGC40179 3p25.3 hypothetical protein MGC40179 MDS027 3p25.3 uncharacterized hematopoietic stem/progenitor cells protein MDS027 VHL 3p26-p25 von Hippel-Lindau syndrome IRAK2 3p25.3 interleukin-1 receptor-associated kinase 2 KIAA0218 3p25.3 interleukin-1 receptor-associated kinase 2 NAG73 3p26-p25 NPC-related protein NAG73 GHRL 3p26-p25 NPC-related protein NAG73 SEC13L1 3p25-p24 SEC13-like 1 (S. cerevisiae) ATP2B2 3p25-p24 ATPase, Ca++ transporting, plasma membrane 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3469 69.3 625 - 1997 9374458
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal DEATH domain
  • lacking a functional kinase domain
  • HOMOLOGY
    interspecies ortholog to Drosophilla Pelle
    Homologene
    FAMILY
  • protein kinase superfamily
  • TKL Ser/Thr protein kinase family
  • PELLE subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • participating to the IL1-induced upregulation of NF-kappaB binding IL1-R1 after IL1 stimulation and binding of IL1R to IL1RAP
  • initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression (
  • is required for LPS-mediated post-transcriptional control of cytokine and chemokine expression, which plays an essential role in TLR4-induced septic shock
  • positive regulator of TLR9-mediated proinflammatory cytokine and chemokine production at some level subsequent to transcription
  • essential role for IRAK2 in primary human cells for both transcriptional and post-transcriptional TLR responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
  • IL1 signaling pathway
  • is a novel and critical component of TGFbeta signaling
  • a component
  • IL-1R signaling complex (pathway) involved in inflammatory diseases
  • MYD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MYD88, 4 IRAK4 and 4 IRAK2 DDs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL1R1
  • plays a key role in the TLR9-mediated transcriptional regulation of IRAK3 expression by sustaining activation of PKD1 and NFKB1
  • is a novel amplifier of the ERN1 pathway
  • IRAK2-TRAF6 interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages (BMDMs) and plasmacytoid dendritic cells (pDCs)
  • induces cell death and inflammatory responses following saturated free fatty acid exposure by activating NFKB1 through a pathway involving IRAK2 expression
  • cell & other
    REGULATION
    activated by IL1
    induced by IL1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS