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FLASH GENE
Symbol IRAK1BP1 contributors: mct/pgu - updated : 18-03-2014
HGNC name interleukin-1 receptor-associated kinase 1 binding protein 1
HGNC id 17368
Location 6q14.1      Physical location : 79.577.188 - 79.608.319
Synonym name
  • ActA binding protein 3
  • signaling molecule that associates with mouse Pelle-like kinase
  • Synonym symbol(s) AIP70, SIMPL, 4921528N06Rik, MGC138458, MGC138460
    DNA
    TYPE functioning gene
    STRUCTURE 31.13 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1157 32.8 295 - 2001 11096118
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region predicted to be intrinsically disordered, binding Hsp70/Hsc70 to stabilize the protein and thereby regulate its activity
  • HOMOLOGY
    interspecies homolog to murine Irak1bp1
    Homologene
    FAMILY
  • IRAK1BP1 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization is required for type I TNF receptor-induced NF-kappaB activity
    basic FUNCTION
  • signaling component required for tumor necrosis factor alpha (TNF-alpha)-dependent but not interleukin-1-dependent NF-kappaB activation
  • regulates transcription of a specific subset of TLR-responsive genes, producing an overall antiinflammatory profile
  • critical factor in preventing dangerous overproduction of proinflammatory cytokines by the innate immune system and in influencing the specificity of TLR responses
  • required for full TNFSRF1A-dependent expression of NF-kappaB-controlled cytokines in endothelial cells
  • down-modulates Toll-like receptor-mediated transcription of several proinflammatory cytokines
  • antiinflammatory role in physiologically relevant conditions and promotes up-regulation of IL10 in macrophages
  • not only involved directly in down-regulation of inflammatory cytokines but also contributing to the state of LPS-induced tolerance
  • inhibits inflammation by promoting nuclear translocation of NFKB1
  • is required for full Tumor Necrosis Factor (TNF) induced NFKB activity
  • functions as a TNF-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNF-induced genes
  • is found in p65-MED1 complexes where IRAK1BP1 enhances p65/MED1/IRAK1BP1 complex formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a signaling pathway through which tumor necrosis factor-alpha (TNF-alpha) induces NF-kappaB-controlled gene transcription
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between IRAK1BP1 and RELA enhances RELA transactivation activity
  • cell & other
    REGULATION
    Other its phosphorylation plays a critical role in IRAK1BP1 regulation by affecting both IRAK1BP1 subcellular localization and the RELA coactivator function of IRAK1BP1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS