basic FUNCTION
| signaling component required for tumor necrosis factor alpha (TNF-alpha)-dependent but not interleukin-1-dependent NF-kappaB activation |
|
regulates transcription of a specific subset of TLR-responsive genes, producing an overall antiinflammatory profile |
|
critical factor in preventing dangerous overproduction of proinflammatory cytokines by the innate immune system and in influencing the specificity of TLR responses |
|
required for full TNFSRF1A-dependent expression of NF-kappaB-controlled cytokines in endothelial cells |
|
down-modulates Toll-like receptor-mediated transcription of several proinflammatory cytokines |
|
antiinflammatory role in physiologically relevant conditions and promotes up-regulation of IL10 in macrophages |
|
not only involved directly in down-regulation of inflammatory cytokines but also contributing to the state of LPS-induced tolerance |
|
inhibits inflammation by promoting nuclear translocation of NFKB1 |
|
is required for full Tumor Necrosis Factor (TNF) induced NFKB activity |
|
functions as a TNF-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNF-induced genes |
|
is found in p65-MED1 complexes where IRAK1BP1 enhances p65/MED1/IRAK1BP1 complex formation |