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FLASH GENE
Symbol IQGAP2 contributors: mct/npt/pgu - updated : 04-10-2017
HGNC name IQ motif containing GTPase activating protein 2
HGNC id 6111
Location 5q13.3      Physical location : 75.699.148 - 76.003.955
DNA
TYPE functioning gene
STRUCTURE 304.88 kb     36 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D5S1977 - IQGAP2 - D5S641 - CKMT2 - D5S626 - D5S428 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 - 4171 122.85 1071 testicular 2004 15621655
  • also called IQGAP2T or tsIQGAP2
  • one WW domain, three IQ motifs, and one RasGAP homology domain
  • potential role during spermatogenesis
  • 36 - 5769 - 1575 - 2004 15621655
    35 - 5460 - 1525 - -
    24 - 4120 - 1071 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly Homo sapiens
     salivary gland   highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivemale systemtestis  highly
    Urinarykidneynephronrenal capsuleglomerulushighly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal calponin homology domain
  • a Ras-GAP related domain six copies of a unique amino-acid motif
  • a single WW domain as well as four IQ motifs also found in unconventional myosins
  • C-terminal IQGAP2 PI binding module reveals unexpected topological similarity to an integral fold of C2 domains, including a putative basic binding pocket
  • HOMOLOGY
    interspecies homolog to yeast S.pombe RasGAP-like protein SAR1
    Homologene
    FAMILY
  • Ras GTPase-activating protein family
  • CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • potential effector for CDC42, may be involved in cell morphology
  • exist as one component of a multifunctional scaffolding complex comprising IQGAP1, beta-catenin, and E-cadherin, with no evidence for direct IQGAP1-IQGAP2 interactions
  • novel tumor suppressor gene specifically linked to the development of hepatocellular carcinoma and the activation of the Wnt/beta-catenin signaling pathway
  • silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development
  • IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor
  • IQGAP2 and AKAP11 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
  • IQGAP1, -2, and -3, are involved in diverse ranges of cellular processes such as adhesion and migration
  • is a RHO-GTPase binding protein, highly abundant in podocytes, which controls normal podocyte structure and function
  • inhibited ovarian cancer cell epithelial-mesenchymal transition, migration and invasion via suppression of Wnt-induced CTNNB1 nuclear translocation and transcriptional activity
  • tumor suppressor predominantly expressed in the liver, is a novel gene putatively required for IFN antiviral response against hepatitis C virus (HCV) infection
  • involvement of IQGAP2 in regulating IFN-stimulated genes (ISG) induction by IFN in an NFKB1-dependent manner
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formation of an IQGAP2-AKAP11 core complex initiates a subsequent phase of protein recruitment that includes the small GTPase Rac
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin cytoskeleton
  • calmodulin
  • activated CDC42 and RAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in the primary gastric cancer tissues as well as gastric cancer cell lines
    tumoral     --low  
    significantly hypermethylated in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Iqgap2 knockout mouse model closely recapitulates human hepatocellular carcinoma (HCC) at the molecular level and supports its further application for the study of this disease