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FLASH GENE
Symbol IQCG contributors: mct - updated : 01-12-2010
HGNC name IQ motif containing G
HGNC id 25251
Location 3q29      Physical location : 197.615.946 - 197.686.886
Synonym symbol(s) FLJ11667, FLJ23571, DKFZp434B227, FLJ37775
DNA
TYPE functioning gene
STRUCTURE 70.94 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2273 51.9 443 - 2006 16344560
11 - 1981 51.9 443 - 2006 16344560
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 neuroendocrinepituitary   
Hearing/Equilibriumear    
Reproductivemale systemtestis   
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain, retained in the fusion protein
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP98-IQCG fusion protein may play an essential role in leukemogenesis, but by itself may not be sufficient to induce leukemia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion between NUP98 and IQ motif containing G (IQCG) gene from a acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS