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FLASH GENE
Symbol IPO8 contributors: mct/npt - updated : 20-05-2009
HGNC name importin 8
HGNC id 9853
Location 12p12.1      Physical location : 30.781.916 - 30.848.929
Synonym name RAN binding protein 8
Synonym symbol(s) RANBP8, FLJ26580, Imp8
DNA
TYPE functioning gene
STRUCTURE 66.83 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PPFIBP1 12q14.3 PTPRF interacting protein, binding protein 1 (liprin beta 1) LOC387849 12 similar to RIKEN cDNA 2210417D09 MRPS35 12p11 mitochondrial ribosomal protein S35 KIAA1340 12p12.1 KIAA1340 protein PTHLH 12p11.2 parathyroid hormone-like hormone FLJ11088 12p11.23 GGA binding partner FLJ10462 12p11.23 hypothetical protein FLJ10462 PTX1 12p11.23 PTX1 protein OVCH1 12p11.23 ovochymase 1 LOC387618 12 hypothetical gene supported by AK125140; NM_194311 ARG99 12p11.23 ARG99 protein IPO8 12p12.1 importin 8 C1QDC1 12p11 C1q domain containing 1 LOC390299 12 similar to Peptidylprolyl isomerase A (cyclophilin A) LOC390300 12 similar to RIKEN cDNA 1110014F12 DDX11 12p11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) DKFZp434C0631 12p11.22 hypothetical protein DKFZp434C0631 LOC387850 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein TERA FLJ13224 12p11.22 hypothetical protein FLJ13224 MGC24039 12p11.22 hypothetical protein MGC24039 MRPL30P2 12p11.2 hypothetical protein MGC24039 LOC341356 12p11.22 similar to ribosomal protein L31 LOC387851 12 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) MGC50559 12p11.22 hypothetical protein MGC50559 LOC196394 12p11.22 hypothetical protein LOC196394 LOC144383 12p11.22 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) LOC283342 12p11.22 similar to H3 histone, family 3B FLJ10652 12p11.22 hypothetical protein FLJ10652 BICD1 12p11.2-p11.1 Bicaudal D homolog 1 (Drosophila) FGD4 12p11.22-p11.21 FGD1 family, member 4 DNM1L q13.11-q14.3 dynamin 1-like CGI-04 12p11.21 CGI-04 protein PKP2 12p11 plakophilin 2 LOC283343 12p11.21 similar to argininosuccinate synthetase SYT10 12 synaptotagmin X LOC390301 12 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 5178 120 1037 - Weinmann (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAN binding site
  • HOMOLOGY
    Homologene
    FAMILY
  • importin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • nuclear import of ribosomal protein
  • nucleocytoplasmic transport
  • required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of AGO proteins (EIF2C) (Weinmann 2009)
  • having specificity factor in the miRNA pathway, which may fulfill additional functions in nuclear Argonaute import (Weinmann 2009)
  • can influence nuclear import of Ago proteins in cells (Weinmann 2009)
  • plays a major role in Ago-mediated gene silencing and in the cytoplasm, localizes together with Ago proteins to P bodies and is involved in efficient loading of Ago proteins onto a variety of different target mRNAs (Weinmann 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    component of miRNA-guided regulatory pathways (Weinmann 2009)
    a component
  • forming a trimeric complex with RANGAP1 and RANBP1
  • component of Ago (Argonaute) protein complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the nuclear pore complex (NPC)
  • binding RAN
  • interacts with Ago proteins and localizes to cytoplasmic processing bodies (P bodies), structures involved in RNA metabolism (Weinmann 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS