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FLASH GENE
Symbol IPO8 contributors: mct/npt - updated : 20-05-2009
HGNC name importin 8
HGNC id 9853
Location 12p12.1      Physical location : 30.781.916 - 30.848.929
Synonym name RAN binding protein 8
Synonym symbol(s) RANBP8, FLJ26580, Imp8
DNA
TYPE functioning gene
STRUCTURE 66.83 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 5178 120 1037 - Weinmann (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAN binding site
  • HOMOLOGY
    Homologene
    FAMILY
  • importin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • nuclear import of ribosomal protein
  • nucleocytoplasmic transport
  • required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of AGO proteins (EIF2C) (Weinmann 2009)
  • having specificity factor in the miRNA pathway, which may fulfill additional functions in nuclear Argonaute import (Weinmann 2009)
  • can influence nuclear import of Ago proteins in cells (Weinmann 2009)
  • plays a major role in Ago-mediated gene silencing and in the cytoplasm, localizes together with Ago proteins to P bodies and is involved in efficient loading of Ago proteins onto a variety of different target mRNAs (Weinmann 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    component of miRNA-guided regulatory pathways (Weinmann 2009)
    a component
  • forming a trimeric complex with RANGAP1 and RANBP1
  • component of Ago (Argonaute) protein complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the nuclear pore complex (NPC)
  • binding RAN
  • interacts with Ago proteins and localizes to cytoplasmic processing bodies (P bodies), structures involved in RNA metabolism (Weinmann 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS