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FLASH GENE
Symbol IPO13 contributors: mct/pgu - updated : 20-08-2011
HGNC name importin 13
HGNC id 16853
Location 1p34.1      Physical location : 44.412.477 - 44.433.693
Synonym name
  • Ran binding protein 13
  • karyopherin 13
  • Synonym symbol(s) IMP13, RANBP13, KIAA0724, KAP13
    DNA
    TYPE functioning gene
    STRUCTURE 21.22 kb     20 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EBNA1BP2 1p35-p33 EBNA1 binding protein 2 FLJ32000 1p34.1 hypothetical protein FLJ32000 LOC256339 1p34.1 similar to ENSANGP00000010412 MGC17299 1p34.1 hypothetical protein MGC17299 MGC52423 1p34.1 hypothetical protein MGC52423 TIE 1p34 tyrosine kinase with immunoglobulin and epidermal growth factor homology domains CDC20 9q13-q21 CDC20 cell division cycle 20 homolog (S. cerevisiae) MPL 1p34 myeloproliferative leukemia virus oncogene ELOVL1 1p34.1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 MED8 1p34.1 mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) LOC388625 1 similar to FLJ00408 protein HT036 1p34.1 hypothetical protein HT036 PTPRF 1p34 protein tyrosine phosphatase, receptor type, F JMJD2 1p34.1 jumonji domain containing 2 SIAT6 1p34.1 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) ARTN 1p32-p31.3 artemin IPO13 1p34.1 importin 13 DPH2L2 1p34 diptheria toxin resistance protein required for diphthamide biosynthesis-like 2 (S. cerevisiae) ATP6V0B 1p32.3 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c'' B4GALT2 1p34-p33 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 MGC45441 1p34.1 hypothetical protein MGC45441 SLC6A9 1p33 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 LOC391034 1 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 FLJ40160 1p34.1 hypothetical protein FLJ40160 LOC128208 1p34.1 similar to dJ675G8.1 (novel zinc finger protein) DMAP1 1p34 DNA methyltransferase 1 associated protein 1 PRNPIP 1p32 prion protein interacting protein FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4041 108 963 - 2001 11447110
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas   lowly
    Nervousbrain   predominantly
    Reproductivemale systemtestis  highly
    Urinarykidney   lowly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text lung, brain, heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG7212
    Homologene
    FAMILY
    CATEGORY transport carrier channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • acting as a mediator of nuclear import and export
  • having functions in myopodin import and the regulation of these events is critical for normal and abnormal cellular differentiation
  • mediates nuclear import of both histone fold heterodimers CHRAC-15/CHRAC-17 and p12/CHRAC-17
  • unusual beta-karyopherin that is able to both import and export cargoes in and out of the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein-nucleus import, docking
    PATHWAY
    metabolism
    signaling
    a component IPO13ľUBE2I9 complex forms in the cytosol and translocates into the nucleus
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARX interacting protein (interaction with the C-terminal of IPO13 nuclear localization sequences in the homeodomain of ARX is required for correct nuclear localization)
  • in the cytoplasm, associates with different cargoes such UBE2I, and facilitates their import into the nucleus where RanGTP binding promotes the release of the cargo
  • CTCF regulates the expression of IPO13, which, in turn, mediates the nuclear import of CTCF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to airway hyperresponsiveness in asthmatic children
    Variant & Polymorphism other
  • IPO13 variation is associated with improved airway hyperresponsiveness in asthmatic children
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS