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FLASH GENE
Symbol IPO11 contributors: mct - updated : 05-01-2013
HGNC name importin 11
HGNC id 20628
Location 5q12.1      Physical location : 61.708.572 - 61.924.415
Synonym name
  • Ran binding protein 11
  • synleurin
  • Synonym symbol(s) RanBP11, SLRN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text in tandem with IPO11, LRRC70
    STRUCTURE 215.84 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391788 5 similar to PDE4D protein LOC389291 5 similar to cAMP-specific phosphodiesterase PDE4D7 LOC391789 5 similar to ribosomal protein L31 LOC345659 5q12.1 similar to template acyivating factor-I alpha PART1 5q12.1 similar to template acyivating factor-I alpha XTP1 5q12.1 HBxAg transactivated protein 1 LOC391790 5 similar to KRT8 protein FLJ23563 5q12.1 hypothetical protein FLJ23563 CKN1 5q11.1-q11.2 Cockayne syndrome 1 (classical) FLJ12595 5q12.1 hypothetical protein FLJ12595 LOC91942 5q12.1 hypothetical protein LOC91942 LOC389292 5 LOC389292 LOC57399 5q12.1 uncharacterized gastric protein ZA52P ZSWIM6 5q12.1 zinc finger, SWIM domain containing 6 FLJ37543 5q12.1-q12.2 hypothetical protein FLJ37543 KIF2 5q12-q13 kinesin heavy chain member 2 HSA9761 5q11-q14 putative dimethyladenosine transferase IPO11 5q12.1 importin 11 LOC246715 5q12.2 cell division control protein CKS1 pseudogene SLRN 5q12.1 synleurin LOC389293 5 similar to hypothetical protein HTR1A 5q11.2-q13 5-hydroxytryptamine (serotonin) receptor 1A LOC285671 5q12.3 hypothetical protein LOC285671 MRPL49P1 5q12.1 hypothetical protein LOC285671 LOC133993 5q12.3 similar to hypothetical protein MGC52498 FLJ36754 5q12.3 hypothetical protein FLJ36754 SDCCAG10 5q12.3 serologically defined colon cancer antigen 10 LOC345667 5q12.3 similar to ADAMTS-10 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 10) (ADAM-TS 10) (ADAM-TS10) ADAMTS6 5pter-qter a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 FKSG14 5p15.2-q12.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 KIAA0073 5q12.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 ARFD1 5q12.3 ADP-ribosylation factor domain protein 1, 64kDa FLJ13611 5q12.3 hypothetical protein FLJ13611 SGTB 5q12.3 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 4420 - 975 - -
    30 - 4420 - 1015 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text anterior rhombomeres, umbilical cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single span transmembrane leucine-rich repeat
  • a LRR central core with 12 analogous LRR repeating modules arranged in a seamless tandem array
  • HOMOLOGY
    Homologene
    FAMILY
  • importin beta superfamily
  • karyopherin family of transport receptors
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • playing synergistic effect on cytokine stimulation
  • constitutively shuttles between the nuclear and cytoplasmic compartments
  • mediator of RPL12 nuclear import
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the Ran GTPase
  • UBE2E3 is a binding partner and potential transport cargo for IPO11
  • RPL12 specifically and directly interacted with importin 11 (IPO11)
  • UBE2E3 is potentially imported into nuclei by the transport receptor importin-11 (IPO11)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS