Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IPO11 contributors: mct - updated : 05-01-2013
HGNC name importin 11
HGNC id 20628
Location 5q12.1      Physical location : 61.708.572 - 61.924.415
Synonym name
  • Ran binding protein 11
  • synleurin
  • Synonym symbol(s) RanBP11, SLRN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text in tandem with IPO11, LRRC70
    STRUCTURE 215.84 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 4420 - 975 - -
    30 - 4420 - 1015 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text anterior rhombomeres, umbilical cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single span transmembrane leucine-rich repeat
  • a LRR central core with 12 analogous LRR repeating modules arranged in a seamless tandem array
  • HOMOLOGY
    Homologene
    FAMILY
  • importin beta superfamily
  • karyopherin family of transport receptors
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • playing synergistic effect on cytokine stimulation
  • constitutively shuttles between the nuclear and cytoplasmic compartments
  • mediator of RPL12 nuclear import
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the Ran GTPase
  • UBE2E3 is a binding partner and potential transport cargo for IPO11
  • RPL12 specifically and directly interacted with importin 11 (IPO11)
  • UBE2E3 is potentially imported into nuclei by the transport receptor importin-11 (IPO11)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS