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FLASH GENE
Symbol IPCEF1 contributors: mct - updated : 10-10-2015
HGNC name interaction protein for cytohesin exchange factors 1
HGNC id 21204
Location 6q25.2      Physical location : 154.475.619 - 154.677.900
Synonym name
  • phosphoinositide-binding protein PIP3-E
  • Synonym symbol(s) PIP3-E
    DNA
    TYPE functioning gene
    STRUCTURE 202.32 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6818 - 438 - 2003 12920129
    12 - 6815 - 437 - 2003 12920129
    13 - 6858 - 438 - 2003 12920129
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliasensory gangliadorsal root   Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to CNKSR3
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the dorsal root ganglions (DRGs) under neuropathic pain conditions
  • is actually the C-terminal half of CNKSR3
  • CNKSR3 and IPCEF1 produce a single protein that is required for HGF dependent ARF6 activation and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with ADP-ribosylation factor GTP exchange factors of the cytohesin family and function by modulating the CYTH2 activity
  • GRASP and IPCEF1 promote ARF-to-RAC1 signaling and cell migration by coordinating the association of CYTH2 with DOCK1
  • scaffold that binds to CYTH2, and is required for cytohesin-induced scattering
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS