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FLASH GENE
Symbol INTS8 contributors: - updated : 11-12-2005
HGNC name integrator complex subunit 8
HGNC id 26048
Location 8q22.1      Physical location : 95.835.533 - 95.892.720
Synonym name chromosome 8 open reading frame 52
Synonym symbol(s) C8orf52, FLJ20530, MGC131633, INT8
DNA
TYPE functioning gene
STRUCTURE 57.00 kb     27 Exon(s)
MAPPING cloned Y linked N status
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunelymph node   highly
Visualeyeanterior segmentcornea highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine Ints8
homolog to chicken ints8
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the RNA polymerase II complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein stably associated with RNAPII
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS