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FLASH GENE
Symbol INTS6 contributors: mct - updated : 23-06-2020
HGNC name integrator complex subunit 6
HGNC id 14879
Location 13q14.3      Physical location : 51.935.701 - 52.027.275
Synonym name
  • murine DBI1 homolog
  • protein deleted in cancer 1
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
  • DEAD box protein
  • protein DDX26
  • RNA helicase HDB
  • Synonym symbol(s) HDB, DBI-1, DICE1, NOTCHL2, DDX26, DDX26A, INT6, DKFZp434B105
    DNA
    TYPE functioning gene
    STRUCTURE 100.16 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 7350 100 887 - 2004 15254679
    3 - 2494 - 115 fetal and adult tissues 2004 15254679
    minor or variant 3
    18 - 6858 - 874 - 2004 15254679
    16 - 7634 - 709 - 2004 15254679
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal DEAD/H (Asp-Glu-Ala-Asp/His) domain
  • a C terminal RNA helicase domain
  • HOMOLOGY
    interspecies homolog to murine Dbi1
    Homologene
    FAMILY
  • DEAD/H box protein family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    text transmembrane
    basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • novel role for INTS6 in restricting the vertebrate organizer to a dorsal domain in embryonic patterning
  • appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer
  • play a tumour suppressing role in certain types of solid tumours
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the RNA polymerase II complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • stably associated with RNAPII
  • in response to the DNA damage response, along with INTS3 and NABP2, INTS6 relocates to the DNA damage sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is associated with a poorer prognosis in hepatocellular carcinoma (HCC) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene for non small cell lung carcinoma,esophageal squamous cell carcinoma and other sporadic carcinomas
    Marker
    Therapy target
    ANIMAL & CELL MODELS