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FLASH GENE
Symbol INTS12 contributors: - updated : 04-04-2006
HGNC name integrator complex subunit 12
HGNC id 25067
Location 4q24      Physical location : 106.603.786 - 106.629.881
Synonym name PHD finger protein 22
Synonym symbol(s) SBBI22, INT12, PHF22
DNA
TYPE functioning gene
STRUCTURE 26.00 kb     8 Exon(s)
MAPPING cloned Y linked N status
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one PHD-type zinc finger
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Phf22
homolog to chicken PHF22
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the integrator complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein stably associated with RNAPII
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS