Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol INTS11 contributors: mct - updated : 07-06-2023
HGNC name integrator complex subunit 11
HGNC id 26052
Corresponding disease
LDIDBA language delay, intellectual disability, and brain atrophy
Location 1p36.33      Physical location : -
Synonym name
  • CPSF3-like protein
  • cleavage and polyadenylation specific factor 3-like
  • protein related to CPSF subunits of 68 kDa
  • Synonym symbol(s) CPSF3L, CPSF73L, INT11, PSF3L, RC-68, RC68, FLJ13294, FLJ20542, CPSF73
    EC.number 3.1.27.-
    DNA
    TYPE functioning gene
    STRUCTURE 13.06 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1811 - 499 - 2023 36822327
    17 - 2114 - 600 - 2023 36822327
    17 - 2221 - 571 - 2023 36822327
    19 - 2587 - 606 - 2023 36822327
    15 - 1820 - 502 - 2023 36822327
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a metallo-beta-lactamase and beta-CASP domain that, together, coordinate two zinc ions within the active site to promote its RNA endonuclease activity
  • C-terminal domain (CTD)
  • HOMOLOGY
    intraspecies paralog to CPSF-73
    Homologene
    FAMILY metallo-beta-lactamase superfamily
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • INTS4, INTS7, INTS9 and INTS11 are both nuclear and cytoplasmic
  • basic FUNCTION
  • INTS4/9/11 are required for Cajal Body integrity
  • INTS11, the catalytic subunit of the Integrator complex, regulates transcription at these loci through its endonuclease activity
  • is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs
  • potential involvement of INTS11 SUMOylation in the assembly of the complex
  • endoribonuclease that catalyzes the cleavage reaction for the 3prime-end processing of pre-mRNAs
  • potential role of metal ions in the activity of CPSF73 and INTS11 for RNA 3prime-end processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • INTS11 forms a stable complex with Integrator complex subunit 9 (INTS9) through their C-terminal domains (CTDs)
  • INTS4/9/11 ternary complex, constitutes Integrator's catalytic core
  • forms a heterotrimer with INTS4 and INTS9 to create what has been termed the “Integrator Cleavage Module"
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • INTS9-INTS11 interaction is crucial for the role of INT in snRNA 3prime-end processing
  • INTS4 binds to INTS9 and INTS11 only when they are associated with each other through heterodimerization of their C-terminal domains
  • is an essential regulator of hematopoietic stem and progenitor cell (HSPC) homeostasis through the INTS11-PRC2 axis
  • BRAT1 tightly interacts with INTS9/INTS11 subunits of the Integrator complex that processes 3' ends of various noncoding RNAs and pre-mRNAs
  • cell & other
    REGULATION
    Other SUMOylation of the INTS11 subunit is regulated by USPL1 and SENP6
    ASSOCIATED DISORDERS
    corresponding disease(s) LDIDBA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS