Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol INTS1 contributors: npt/mct/pgu - updated : 02-09-2009
HGNC name integrator complex subunit 1
HGNC id 24555
Location 7p22.3      Physical location : 1.509.912 - 1.544.018
Synonym symbol(s) KIAA1440, INT1, DKFZp586J0619
DNA
TYPE functioning gene
STRUCTURE 34.10 kb     48 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
48 - 7000 244 2190 - 2005 16239144
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • integrator subunit 1 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text predominantly nuclear localization
    basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • largest subunit of the integrator complex, which mediates U1 and U2 snRNA 3'-end processing
  • play non-redundant roles in the cell such as the formation of a scaffold for the assembly of the integrator complex
  • INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the RNA polymerase II complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stably associated with RNAPII
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    developing KIAA1440(-/-) mouse embryo in a pure ICR background arrests its growth at the early blastocyst stage, whereas the majority of the KIAA1440(-/-) embryos of mixed genetic backgrounds do not progress beyond the morula stage, approximately 0.5 days earlier