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FLASH GENE
Symbol INSIG2 contributors: SGE/npt - updated : 18-06-2008
HGNC name insulin induced gene 2
HGNC id 20452
Location 2q14.2      Physical location : 118.846.049 - 118.867.596
Synonym name
  • INSIG2 membrane protein
  • insulin-induced gene 2 protein
    • Synonym symbol(s) LOC51141, MGC26273, INSIG-2
    DNA
    TYPE functioning gene
    STRUCTURE 21.55 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure an Ets-consensus motif in the proximal region of the promoter, binding phosphorylated ELK4 (Fernández-Alvarez 2010)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2592 24.8 225 - Yabe (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    nervousbraindiencephalon   
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane helices
    • HOMOLOGY
    interspecies homolog to murine Insig2 (96.9pc)
    homolog to rattus Insig2 (96.4pc)
    intraspecies homolog to INSIG1
    Homologene
    FAMILY
  • INSIG family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • negative regulator of cholesterol synthesis
  • involved in adipocyte metabolism and body weight regulation
  • in the presence of sterols, INSIG2 regulates lipid synthesis by blocking the proteolytic activation of SREBPs by SCAP and causing SREBPs to be retained in the ER (Yabe 2002)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with SCAP (to block export of sterol regulatory element-binding proteins)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to severe obesity
    Variant & Polymorphism SNP significantly associated with obesity
    Candidate gene putative positive prognostic biomarker for colon cancer prognosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS