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FLASH GENE
Symbol INPP5B contributors: mct - updated : 01-10-2014
HGNC name inositol polyphosphate-5-phosphatase, 75kDa
HGNC id 6077
Location 1p34.3      Physical location : 38.326.368 - 38.412.729
Synonym symbol(s) ITPP5B
EC.number 3.1.3.5/ 3.1.3.36
DNA
TYPE functioning gene
STRUCTURE 86.36 kb     24 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3952 - 749 - 1995 8529643
24 - 4469 - 913 - 1995 8529643
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal proline rich domain
  • a central 5 phosphatase domain
  • a C terminal CAAX domain
  • HOMOLOGY
    intraspecies paralog to OCRL
    Homologene
    FAMILY inositol polyphosphate 5-phophatase subfamilies
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • is localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC)
  • basic FUNCTION
  • involved in signal terminating reaction in the inositol signaling pathway and in regulation of Golgi vesicular trafficking
  • role for INPP5B in retrograde ERGIC-to-ER transport and imply that it has functions distinct from those of OCRL within both the secretory and endocytic pathways
  • functional overlap of OCRL and INPP5B in most cell lineages, especially in extraembryonic tissues
  • OCRL and INPP5B are differentially expressed in the human and murine eyes, and play compensatory roles in cilia development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    inositol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB binding is required for efficient Golgi targeting of INPP5B
  • partial functional redundancy between INPP5B and OCRL for primary cilia assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS