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FLASH GENE
Symbol INPP4A contributors: mct/npt - updated : 18-08-2007
HGNC name inositol polyphosphate-4-phosphatase, type I, 107kDa
HGNC id 6074
Location 2q11.2      Physical location : 99.061.320 - 99.207.495
Synonym name type I inositol-3,4-bisphosphate 4-phosphatase
Synonym symbol(s) IP4P, INPP4
EC.number 3.1.3.66
DNA
TYPE functioning gene
STRUCTURE 68.70 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 splicing 3217 110 938 major isoform in platelets Norris, Hillier (2005)
  • hydrophobic C terminus
  • having a novel domain, proline rich and containing a PEST sequence characteristic of proteins that are rapidly degraded by the calpain family of proteases
  • 25 splicing 3224 - 954 - Norris, Hillier (2005)
    hydrophobic C terminus
    - - 6752 110 977 - Hillier (2005)
    - - 6737 - 972 - Hillier (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart    
    Nervousbrain   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proline rich domain containing a PEST sequence
  • HOMOLOGY
    interspecies homolog to murine Inpp4a
    Homologene
    FAMILY
  • inositol-3,4-bisphosphate 4-phosphatase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyze the hydrolysis of the D-4 position phosphoester of the PI3K generated lipid second messenger, phosphatidylinositol 3,4-bisphosphate (Shearn 2001)
  • generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations (Ivetac 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    phosphatidylinositol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS