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FLASH GENE
Symbol INMT contributors: mlc/np - updated : 22-03-2004
HGNC name indolethylamine N-methyltransferase
HGNC id 6069
Location 7p15.3-p15.2      Physical location : 30.791.750 - 30.797.218
Synonym name
  • amine N-methyltransferase
  • nicotine N-methyltransferase
  • arylamine N-methyltransferase
  • thioester S-methyltransferase-like
  • Synonym symbol(s) MGC125940, MGC125941
    EC.number 2.1.1.49
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    COPG2 7q32 coatomer protein complex, subunit gamma 2 Ells1 7p15.1 hypothetical protein Ells1 SES1 7p14.3-p14.1 secernin 1 LOC223082 7p15.1 zinc finger/RING finger 2 TSGA13 7q32 testis specific, 13 KLF14 7q32.3 Kruppel-like factor 14 FKBP14 7p15.3 FK506 binding protein 14, 22 kDa DKFZp586I1420 7p15.1 hypothetical protein DKFZp586I1420 FAPP2 7p21-p11.2 phosphoinositol 4-phosphate adaptor protein-2 CARD4 7p15-p14 caspase recruitment domain family, member 4 Ells1 7p15.1 hypothetical protein Ells1 C7orf24 7p15-p14 chromosome 7 open reading frame 24 LOC392791 7 LOC392791 LOC392792 7 hypothetical gene supported by AK125651; BC039420 GARS 7p15 glycyl-tRNA synthetase LOC223082 7p15.1 zinc finger/RING finger 2 CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 DKFZp586I1420 7p15.1 hypothetical protein DKFZp586I1420 INMT 7p15.3-p15.2 indolethylamine N-methyltransferase LOC392651 7 similar to hypothetical protein FLJ22374 CARD4 7p15-p14 caspase recruitment domain family, member 4 C7orf24 7p15-p14 chromosome 7 open reading frame 24 LOC392987 7 similar to ribosomal protein L27 AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) GARS 7p15 glycyl-tRNA synthetase MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs GHRHR 7p14 growth hormone releasing hormone receptor CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I INMT 7p15.3-p15.2 indolethylamine N-methyltransferase FLJ22374 7p15.1 hypothetical protein FLJ22374 PODXL 7q32-q33 podocalyxin-like AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) LOC392793 7 similar to eukaryotic translation elongation factor 1 beta 2; eukaryotic translation elongation factor 1 beta 1 LOC392988 7 similar to ribosomal protein S14 GHRHR 7p14 growth hormone releasing hormone receptor NEUROD6 7p15.3 neurogenic differentiation 6 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I LOC223075 7p15.1 hypothetical protein LOC223075 NEUROD6 7p15.3 neurogenic differentiation 6 C7orf16 7p15 chromosome 7 open reading frame 16 PLXNA4 7q32.3 plexin A4 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa LOC223075 7p15.1 hypothetical protein LOC223075
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2639 28 263 - Hillier (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to indoleamines and beta carbolines,structurally
    Homologene
    FAMILY NNMT/PNMT/TEMT family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the N methylation of the tryptamine, serotonine and structurally related compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS