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FLASH GENE
Symbol INIP contributors: mct - updated : 23-06-2020
HGNC name INTS3 and NABP interacting protein
HGNC id 24994
Location 9q32      Physical location : -
Synonym name
  • HSPC043 protein
  • hypothetical protein LOC58493
  • chromosome 9 open reading frame 80
  • minute INTS3/hSSB-associated element
  • sensor of single-strand DNA complex subunit C
  • sensor of ssDNA subunit C
  • Synonym symbol(s) HSPC043, SOSSC, C9orf80, MISE, SSBIP1, hSSBIP1
    DNA
    TYPE functioning gene
    STRUCTURE 34.19 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1532 - 104 - 2018 29150435
    6 - 4207 - 74 - 2018 29150435
    6 - 4258 - 101 - 2018 29150435
    4 - 4023 - 85 - 2018 29150435
    4 - 4011 - 81 - 2018 29150435
    4 - 4033 - 74 - 2018 29150435
    5 - 4126 - 74 - 2018 29150435
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in response to DNA damage stimulus
  • CELLULAR PROCESS nucleotide, repair, recombination
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with INST3 and OBFC2B or OBFC2A, complex which is required for efficient homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-dependent signaling pathways (Li 2009)
  • SOSS complex (NABP1, NABP2, INTS3, INIP) is likely involved in the maintenance of genome stability
  • components of the NABP2/NABP3-INTS3-C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maintenance of genome stability
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSBP1 and SSBP2 form separate complexes with two identical proteins, INTS3 and C9ORF80
  • INIP binds ssDNA but not ssRNA
  • INTS3, but not C9ORF80, affects the nucleic acid-binding ability of NABP1 and NABP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS