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FLASH GENE

Symbol

INHBB

contributors: mct/npt - updated : 13-11-2009

HGNC name	inhibin, beta B
HGNC id	6067

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q14.2      Physical location : 121.103.718 - 121.109.383
Synonym name	inhibin, beta B (activin AB beta polypeptide)
	activin beta-B chain
Synonym symbol(s)	MGC157939

DNA

TYPE	functioning gene
STRUCTURE	5.66 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002193 2 - 3218 NP_002184 - 407 - Makanji (2009)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland medulla       endocrine brain diencephalon pituitary     Endocrine thyroid       highly Nervous nerve cranial nerve     highly Reproductive male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Nervous autonomous       Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve not specific adipocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

homomer , heteromer , dimer

isoforms

Precursor

HOMOLOGY

interspecies	homolog to murine Inhbb
	homolog to C.elegans T25F10.2

Homologene

FAMILY	TGF-beta family
	BMP family

CATEGORY

signaling hormone growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	regulating gonadal stromal cell proliferation negatively
	having tumour-suppressor activity
	may have local effects in adipose tissue and thereby influence obesity and its comorbidities (Carlsson 2009)
	negatively regulate the release of FSH from the anterior pituitary (Makanji 2009)

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

hormonal

a component	dimerizing with INHA to form inhibin a pituitary FSH secretion inhibitor
	homodimerizing or heterodimerizing with INHBA to form activin B or respectively AB,stimulating FSH secretion
	homodimerization of two INHBB subunits results in formation of activin B (Carlsson 2009)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

negative regulator of gonadal stromal cell proliferation

REGULATION

induced by

BMP6, in granulosa cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9 in colorectal cancer tumoral     --low   in pheochromocytoma constitutional     --over   in adipocytes, and adipose tissue INHBB mRNA levels correlated to metabolic risk factors (Sjoholm 2006) constitutional     --over   the exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis (Mahmoud 2005)

Susceptibility

Variant & Polymorphism

Candidate gene	marker of Sertoli cell function and spermatogenesis (Mahmoud 2005)
Marker
Therapy target

ANIMAL & CELL MODELS