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FLASH GENE
Symbol INHA contributors: - updated : 07-10-2006
HGNC name inhibin, alpha
HGNC id 6065
Location 2q33-q34      Physical location : 220.436.953 - 220.440.427
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbrain    
 spinal cord    
Reproductivefemale systemovary   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
isoforms Precursor
HOMOLOGY
Homologene
FAMILY
  • TGFB superfamily member
  • BMP family
  • CATEGORY tumor suppressor , signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be both a growth/differentiation factor and a hormone
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text neuroregulatory functions
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • dimeric, linked by one or more disulfide bonds
  • inhibin A is a dimer of alpha and beta-A
  • inhibin B is a dimer of alpha and beta-B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other negative regulator of gonadal stromal cell proliferation
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer, not detectable in poorly differentiated tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS