Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ING3 contributors: mct - updated : 15-06-2010
HGNC name inhibitor of growth family, member 3
HGNC id 14587
Location 7q31.31      Physical location : 120.590.816 - 120.615.702
Synonym name p47ING3 protein
Synonym symbol(s) P47ING3, FLJ20089, Eaf4, p47, ING2, MEAF4
DNA
TYPE functioning gene
STRUCTURE 24.90 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GASZ 7q31.31 GASZ CFTR 7q31.3 cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) CORTBP2 7q31.3 cortactin binding protein 2 LSM8 7q31.1-q31.3 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) ANKRD7 7q31 ankyrin repeat domain 7 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 RNF133 7q31.33 ring finger protein 133 RNF148 7q31.33 ring finger protein 148 TAS2R16 7q31.1-q31.3 taste receptor, type 2, member 16 SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 FLJ35834 7q31.33 hypothetical protein FLJ35834 NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 LOC389550 7 similar to cardiac leiomodin WASL 7q31.3 Wiskott-Aldrich syndrome-like HYAL4 7q31.3 hyaluronoglucosaminidase 4 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC340344 7q31.33 similar to RIKEN cDNA 6332401O19 gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2221 46 418 - 2006 16387653
- splicing 1240 - 92 - 2006 16387653
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta  highly
Digestiveliver    
Lymphoid/Immunespleen   highly
 thymus    
Reproductivemale systemtestis  highly
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PHD-finger motif (zinc finger), highly homologous among ING family proteins
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Ing3
    homolog to Xenopus Xl.14468
    homolog to rattus Rn.76174
    Homologene
    FAMILY
  • ING family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a transcription factor by promoter activation
  • regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of TP53
  • promotes UV-induced apoptosis via the Fas/caspase-8-dependent pathway in melanoma cells
  • would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • stable components of the SIN3A /HDAC and KAT5/NuA4 HAT complexes
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • zn2+
  • protein
  • RPS6KA1 regulates anchorage-independent growth through transcriptional regulation of factors that modulate cell survival, including ING3, CKAP2, and PTK6
  • cell & other
    REGULATION
    Other degraded by the ubiquitin-proteasome pathway through the KITLG(SKP2) complex and interruption of ING3 degradation enhances the tumor-suppressive function of ING3, which provides a potential cancer therapeutic approach by interfering ING3 degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation LOH    
    in tongue and larynx squamous cell carcinomas and in head and neck squamous cell carcinoma
    tumoral somatic mutation   --low  
    in tongue and larynx squamous cell carcinomas with tendency of higher mortality
    tumoral     --low  
    may be associated with melanoma progression
    tumoral     --low  
    nuclear expression was remarkably reduced in malignant melanomas compared with dysplastic nevi (P<0.001), which was significantly correlated with the increased ING3 level in cytoplasm
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may be an important marker for melanoma progression
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    prognosis as well as a potential therapeutic target
    ANIMAL & CELL MODELS