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FLASH GENE
Symbol INCENP contributors: mct/npt - updated : 10/11/2009
HGNC name inner centromere protein antigens 135/155kDa
HGNC id 6058
Location 11q12.3      Physical location : 61.891.444 - 61.920.635
Synonym name
  • chromosomal passenger protein
  • binds and activates aurora-B and -C in vivo and in vitro
  • Synonym symbol(s) FLJ31633, MGC111393
    DNA
    TYPE functioning gene
    STRUCTURE 29.19 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4146 - 918 - Wong (2007)
    18 - 4134 - 914 - Wong (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
     male systemprostate  highly
    cell lineage
    cell lines colorectal cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • centromere targeting and transfer to the spindle region
  • multiple nuclear localization signals
  • chromosome binding region and spindle midzone targeting
  • coiled coil domain (microtubules binding site)
  • mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Incenp
    Homologene
    FAMILY
  • INCENP family
  • CATEGORY structural protein , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,nucleolus
    text
  • localized to metaphase chromosomes and to the mitotic spindle and equatorial cortex at anaphase and also in the cleavage furrow
  • cytoplasmic face of the plasma membrane
  • as mitosis progresses, with Survivin, Aurora B, CDCA8 dynamically colocalize to mitotic structures
  • accumulate in the interphase nucleolus in an RNA polymerase I-dependent manner (Wong 2007)
  • basic FUNCTION
  • required for chromosome segregation and the onset of cytokinesis during mitosis
  • moves from the central spindle to the furrow of a dividing cell by a KIF12-dependent pathway (once INCENP reaches the equatorial cortex, it associates with the actin cytoskeleton where it then concentrates toward the end of cytokinesis) (Chen 2007)
  • playing a role in the regulation of sister chromatid separation in mitosis (loss of INCENP is accompanied by loss of cohesion)
  • essential for central spindle and midbody localization of chromosomal passenger complex
  • plays a catalytic role in AURKB autophosphorylation (Yang 2009)
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with BIRC5 that links centromere to microtubules
  • interacts with CDCA8, AURKB and BIRC5 to form the chromosomal passenger complex (CPC), which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CBX3, tubulin beta chain
  • binding partner Aurora-B/AIMdetected at the inactive centromere)-1 kinase (both can be)
  • binds and activates Aurora-C
  • associating with CDCA8
  • interacting with BIRC5 on the localization of Aurora B and CDCA8, respectively (different complexes of chromosomal passenger proteins may exist not only during mitosis, but also before NEB (nuclear envelope breakdown )
  • interacting with CENPV
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly higher nuclear expression in high grade B-cell lymphomas versus low grade ones (Barbanis 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS